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Journal of Pharmacology And Experimental Therapeutics, Vol. 43, Issue 1, 147-162, 1931
Copyright © 1931 by American Society for Pharmacology and Experimental Therapeutics

HEAT REGULATION AND WATER EXCHANGE XII. THE UNDERLYING MECHANISM OF FEVER AS ILLUSTRATED BY COCAINE POISONED RABBITS

HENRY G. BARBOUR 1 and HUBERT T. MARSHALL 1

1 From the Department of Physiology and Pharmacology, School of Medicine, University of Louisville, Kentucky

1. Following pyretic doses of cocaine in the rabbit (20 to 40 mgm. per kilogram) there was a definite loss of fluid from the blood.

2. Neither brain, muscle nor kidney of the febrile animals showed significant change in water content. The skin possibly lost some fluid.

3. During the rise in rectal temperature there was an increase in the water content of the liver. The average decrease in liver solids amounted to 7.5 per cent. This would account for an addition of about 5 cc. of water to the liver while an average figure for the amount of water lost from the blood was about 6 cc. The water shift was complete within the first half-hour.

4. No evidence of deposition of fluid in the pleural, pericardial or peritoneal cavities was found.

Submitted on May 7, 1931






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Copyright © 1931 by the American Society for Pharmacology and Experimental Therapeutics.