JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 42, Issue 2, 217-231, 1931
Copyright © 1931 by American Society for Pharmacology and Experimental Therapeutics

CHRONIC EXPERIMENTAL BARBITAL POISONING

M. H. SEEVERS 1 and A. L. TATUM 1

1 From the Department of Pharmacology of the University of Wisconsin, Madison

1. Chronic barbital poisoning in dogs reveals: (a) A slight grade of tolerance existing for a time; (b) following the more tolerant period, a static stage, which in turn is followed by a stage of intolerance.

2. Damage to the central nervous system occurs, which can be related to progress and symptomatology of the chronic poisoning.

3. Experimental evidences herein presented furnish a basis for a more thorough understanding of the problems involved in chronic poisoning and addiction to barbiturates in man.

Submitted on January 23, 1931






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Copyright © 1931 by the American Society for Pharmacology and Experimental Therapeutics.