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Journal of Pharmacology And Experimental Therapeutics, Vol. 42, Issue 1, 27-34, 1931
Copyright © 1931 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF SODIUM PHENOBARBITAL AND THE ANTAGONISM OF MORPHINE TO PHENOBARBITAL AND TO PITUITARY EXTRACT IN INTACT INTESTINE IN NON-ANESTHETIZED DOGS

C. M. GRUBER 1, W. M. CRAWFORD 1, W. W. GREENE 1, and C. S. DRAYER 1

1 From the Department of Pharmacology, Washington University, School of Medicine, Saint Louis, Missouri

1. Sodium phenobarbital in most instances when injected intravenously in large doses, causes a lowering of general tonus of the Thiry-Vella loop of intestine in non-anesthetized dogs.

2. Morphine sulphate counteracts the effect of sodium phenobarbital and in most instances sodium phenobarbital will lower the increased general tonus produced in the gut by a previous injection of morphine.

3. Morphine sulphate causes an increase in the general tonus of the intestine even though the tonus has been lowered by a previous injection of pituitary extract.

4. Pituitary extract temporarily lowers the increased general tonus of the intestine produced by the injection of morphine sulphate.

Submitted on December 5, 1930






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