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Journal of Pharmacology And Experimental Therapeutics, Vol. 41, Issue 1, 47-64, 1931
Copyright © 1931 by American Society for Pharmacology and Experimental Therapeutics

STUDIES IN MERCURIAL CHEMOTHERAPY II. THE QUANTITATIVE EVALUATION OF MERCURIAL DIURESIS AND ITS RELATION TO CHEMICAL CONSTITUTION

ERNEST FOURNEAU 1 and KENNETH I. MELVILLE 1

1 Laboratoire de Chimie Thérapeutique, Institut Pasteur, Paris, France

An attempt has been made to obtain a definite numerical evaluation of the diuretic activity of mercury compounds, based upon their "chemotherapeutic coefficient" (diuretically), and their ability to increase quantitatively urinary elimination in rabbits kept under certain specified conditions of water elimination.

Comparative studies of eighteen mercury compounds upon such a basis have been carried out.

The results indicate that qualitatively, all the soluble mercury compounds studied led to diuresis, but quantitatively definite variations in such diureses could be observed. Structural changes in chemical constitution might lead to variations in diuretic activity, and differences in the solubility of the acid organic compounds in alkali, seem an important factor.

Submitted on August 11, 1930




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 Arch Intern MedHome page
T. SOLLMANN and N. E. SCHREIBER
COMPARATIVE DIURETIC RESPONSE TO CLINICAL INJECTIONS OF VARIOUS MERCURIALS
Arch Intern Med, December 1, 1936; 58(6): 1067 - 1086.
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