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Journal of Pharmacology And Experimental Therapeutics, Vol. 40, Issue 3, 305-325, 1930
Copyright © 1930 by American Society for Pharmacology and Experimental Therapeutics

CHLOROFORM CONTENT IN VARIOUS TISSUES DURING ANESTHESIA AND ITS RELATIONSHIP TO THE THEORIES OF NARCOSIS

JAMES L. McCOLLUM 1

1 Department of Pharmacology, University of Toronto

1. The solubility of chloroform in water at 37.5°C. is 1 gram per 100 cc.

2. The partition coefficient of chloroform between olive oil and water at 37.5°C. is 110.

3. Corpuscles contain more chloroform than the plasma and more than their additional lipoid content warrants.

4. Anesthesia is produced when the brain cells contain about half the amount of chloroform that they can contain without the death of the animal. The passage of chloroform into the brain cells is progressive.

5. The data presented in this paper do not support the Meyer-Overton hypothesis of anesthesia.

Submitted on July 28, 1930






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Copyright © 1930 by the American Society for Pharmacology and Experimental Therapeutics.