JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DAVID, J. C.
Right arrow Search for Related Content
PubMed
Right arrow Articles by DAVID, J. C.
Journal of Pharmacology And Experimental Therapeutics, Vol. 40, Issue 2, 229-234, 1930
Copyright © 1930 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF DRUGS ON THE OXYGEN CONSUMPTION OF THE FROG'S ISOLATED AURICLE

J. CHRISTODOSS DAVID 1

1 From the Department of Pharmacology, University of Edinburgh

1. A method is described for introducing drugs into an isolated auricle without disturbing the measurements of the oxygen consumption.

2. The action of three drugs on the oxygen consumption of the frog's isolated auricle was measured.

3. a. Adrenaline causes a percentage increase in oxygen consumption slightly greater than the percentage increase in frequency of beat.

b. Strophanthin causes a decrease in both oxygen consumption and in frequency of beat; sub-lethal concentrations cause a temporary initial increase in oxygen consumption.

c. Pilocarpine causes a percentage decrease in oxygen consumption that is greater than the percentage decrease in frequency of beat.

Submitted on June 24, 1930






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1930 by the American Society for Pharmacology and Experimental Therapeutics.