THE INFLUENCE OF DRUGS ON THE TRANSMISSION OF ARSENIC INTO THE AQUEOUS HUMOR

¹ From the Department of Surgery, Yale Medical School

After intravenous injections of arsphenamine, neoarsphenamine, silver arsphenamine, sulpharsphenamine and trypharsamide, the instillation of pilocarpine into conjunctival sac causes an increase in the amount of arsenic in the aqueous humor. Eserine after intravenous injection of neoarsphenamine and sulpharsphenamine and arecoline after the injection of sulpharsphenamine gives a similar effect. Repeated paracentesis of the anterior chamber of the eye after injection of the arsenicals results in an equal concentration of arsenic in the aqueous humor. Little or no arsenic enters the spinal fluid of the normal dog. The action of the myotics on the eye generally results in an increase of protein with an accompanying increase of arsenic.