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Journal of Pharmacology And Experimental Therapeutics, Vol. 39, Issue 1, 39-57, 1930
Copyright © 1930 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE COLLOID CHEMISTRY OF ANTISEPSIS AND CHEMOTHERAPY IV. THE DUPLICATION IN VITRO OF THE "INTERFERENCE PHENOMENON" IN COMBINATION CHEMOTHERAPY

HAROLD N. WRIGHT 1 and ARTHUR D. HIRSCHFELDER 1

1 From the Department of Pharmacology, University of Minnesota

1. The interference of acriflavine against the trypanocidal action of triphenyl methane dyes observed by Browning and Schnitzer in animals, a phenomenon of "drug-fastness," can be duplicated in vitro upon the CO2 production of yeasts.

2. This reaction appears to be a phenomenon due to adsorption of the first dye upon the surface of the cell interfering with the adsorption of the second.

3. This analogy should furnish a means for studying further questions of drug-fastness and for further physico-chemical investigation of many questions in chemotherapy.

Submitted on February 27, 1930






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Copyright © 1930 by the American Society for Pharmacology and Experimental Therapeutics.