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Journal of Pharmacology And Experimental Therapeutics, Vol. 38, Issue 1, 85-99, 1930
Copyright © 1930 by American Society for Pharmacology and Experimental Therapeutics

SIMULTANEOUS RECORDING OF PERISTALSIS AND ACTION OF THE PYLORIC VALVE IN THE ISOLATED STOMACH OF THE FROG I. THE INFLUENCE OF ACIDITY AND BASICITY

JESSE L. SERBY 1 and M. S. DOOLEY 1

1 Department of Pharmacology, College of Medicine, Syracuse University

1. A brief review of the literature is given, indicating that the oncometric method described has not been employed previously for the study of the activities of the isolated stomach.

2. This method affords visualization; is relatively free from mechanical interferences, thus facilitating more accurate interpretation of graphic records.

3. Normal motor activities are described.

4. The effects of acidity and basicity are described. The former favors peristalsis and a freer outflow from the stomach, at the same time increasing the tone. The latter increases the number of antiperistaltic waves. Evidence is presented indicating that pyloric obstruction is in large part responsible for the occurrence of these waves.

Submitted on November 13, 1929






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