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PERSPECTIVES IN PHARMACOLOGY

Regulation and Pathological Role of p53 in Cisplatin Nephrotoxicity

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia (M.J., Z.D.); and Charlie Norwood VA Medical Center, Augusta, Georgia (Z.D.)

Cisplatin is one of the most potent chemotherapy drugs widely used for cancer treatment. However, its use is limited by side effects in normal tissues, particularly the kidneys. Recent studies, using both in vitro and in vivo experimental models, have suggested a critical role for p53 in cisplatin nephrotoxicity. The signaling pathways upstream and downstream of p53 are being investigated and related to renal cell injury and death. Along with the mechanistic studies, renoprotective approaches targeting p53 have been suggested. Further research may integrate p53 signaling with other nephrotoxic signaling pathways, providing a comprehensive understanding of cisplatin nephrotoxicity and leading to the development of effective renoprotective strategies during cancer therapy.

Address correspondence to. Dr. Zheng Dong, Department of Cellular Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Blvd., Augusta, GA 30912. E-mail: zdong{at}mail.mcg.edu

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				M. Jiang, C.-Y. Wang, S. Huang, T. Yang, and Z. Dong Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway Am J Physiol Renal Physiol, May 1, 2009; 296(5): F983 - F993. [Abstract] [Full Text] [PDF]

				K. Singaravelu, K. Devalaraja-Narashimha, B. Lastovica, and B. J. Padanilam PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia Am J Physiol Renal Physiol, April 1, 2009; 296(4): F847 - F858. [Abstract] [Full Text] [PDF]