QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: jpet.106.113183v1 321/2/423    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mager, D. E. Articles by Abernethy, D. R. Search for Related Content PubMed PubMed Citation Articles by Mager, D. E. Articles by Abernethy, D. R.

PERSPECTIVES IN PHARMACOLOGY

Use of Wavelet and Fast Fourier Transforms in Pharmacodynamics

Department of Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, New York (D.E.M.); and National Institute on Aging, National Institutes of Health, Gerontology Research Center, Baltimore, Maryland (D.R.A.)

Progress has been made in the development and application of mechanism-based pharmacodynamic models for describing the drug-specific and physiological factors influencing the time course of responses to the diverse actions of drugs. However, the biological variability in biosignals and the complexity of pharmacological systems often complicate or preclude the direct application of traditional structural and nonstructural models. Mathematical transforms may be used to provide measures of drug effects, identify structural and temporal patterns, and visualize multidimensional data from analyses of biomedical signals and images. Fast Fourier transform (FFT) and wavelet analyses are two methodologies that have proven to be useful in this context. FFT converts a signal from the time domain to the frequency domain, whereas wavelet transforms colocalize in both domains and may be utilized effectively for nonstationary signals. Nonstationary drug effects are common but have not been well analyzed and characterized by other methods. In this review, we discuss specific applications of these transforms in pharmacodynamics and their potential role in ascertaining the dynamics of spatiotemporal properties of complex pharmacological systems.

Address correspondence to: Dr. Darrell R. Abernethy, National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224. E-mail: abernethyd{at}grc.nia.nih.gov

This article has been cited by other articles:

				D. E. Mager, E. Kobrinsky, A. Masoudieh, A. Maltsev, D. R. Abernethy, and N. M. Soldatov Analysis of Functional Signaling Domains from Fluorescence Imaging and the Two-Dimensional Continuous Wavelet Transform Biophys. J., October 15, 2007; 93(8): 2900 - 2910. [Abstract] [Full Text] [PDF]