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NEUROPHARMACOLOGY

Heterogeneous Dopamine Neurochemistry in the Striatum: The Fountain-Drain Matrix

Laboratory of Neurobiology and Experimental Neurology, Department of Physiology (M.R., I.M., I.G., S.G., J.L.G.-M.) and Department of Anatomy (T.G.-H.), Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain

In contrast to the relatively high attention paid to the structural heterogeneity of striatal dopamine (DA) innervation, little attention has been focused on the possible striatal heterogeneity for release and uptake of DA. By using amperometric methods, we found striatal regions showing a DA decrease during the medial forebrain bundle stimulation (drain areas) near to other zones that showed an increase in DA concentration (fountain areas). Both areas were intermixed to form a tridimensional matrix to regulate DA concentration throughout the striatum (fountain-drain matrix). The response to electrical stimuli of different amplitudes and durations and to different drugs (-methyl-L-tyrosine, cocaine, -butyrolactone, and haloperidol) suggests that regional differences for both DA release/DA uptake and DA cell firing autoregulation are behind the striatal fountain-drain matrix. The high diversity of DA activity observed in the striatum is a new framework for analyzing experimental and clinical phenomena.

Address correspondence to: Dr. Manuel Rodríguez Díaz, Departamento de Fisiologia, Facultad de Medicina, Universidad de La Laguna, 38320 Tenerife, Canary Islands, Spain. E-mail: mrdiaz{at}ull.es