QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: jpet.106.105973v1 319/1/111    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gebhard, C. Articles by Grenz, A. Search for Related Content PubMed PubMed Citation Articles by Gebhard, C. Articles by Grenz, A.

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Role of Renal Nerves and Salt Intake on Erythropoietin Secretion in Rats following Carbon Monoxide Exposure

Departments of Pharmacology and Toxicology (C.G., H.Z., D.K., C.K., M.A., C.H.G., H.O., A.G.), Oral and Maxillofacial Surgery (F.P.), and Molecular Pathology (K.K.), University Hospital Tuebingen, Tuebingen, Germany

Because the data from the literature contain conflicting results regarding the role of renal nerves and angiotensin II in hypoxia-induced erythropoietin (EPO) secretion, we evaluated the effect of renal nerves and salt intake in rats on EPO secretion stimulated by carbon monoxide (CO). Serum levels and renal mRNA content of EPO were similarly elevated by exposure to different CO concentrations in a dose-dependent manner in rats with bilateral renal denervation (DNX) and in sham-denervated controls (INN). However, at 600 ppm CO, serum concentrations and mRNA of EPO were significantly higher in DNX compared with INN rats (p < 0.05). This increase of EPO secretion in DNX rats could be blocked by administration of neuropeptide Y (NPY) (p < 0.05), whereas the NPY receptor antagonist did not enhance EPO secretion in INN rats after CO exposure. Agonists and antagonists of -adrenergic receptors had no effect on EPO secretion. High-salt (HS) diet reduced EPO secretory response at 600 ppm CO by 55% compared with INN rats on normal salt diet (p < 0.01). In addition, DNX increased EPO secretion in rats on low-salt and HS diet, whereas plasma renin activity did not correlate with EPO levels under these experimental conditions. In summary, our data suggest that renal nerves contribute to the half-maximal EPO secretory response to CO exposure, possibly via NPY receptors.

Address correspondence to: Dr. Almut Grenz, Department of Pharmacology and Toxicology, University Hospital Tuebingen, D-72074 Tuebingen, Germany. E-mail: almut.grenz{at}uni-tuebingen.de

This article has been cited by other articles:

				A. Grenz, H. Zhang, J. Weingart, S. von Wietersheim, T. Eckle, J. Schnermann, C. Kohle, D. Kloor, C. H. Gleiter, V. Vallon, et al. Lack of effect of extracellular adenosine generation and signaling on renal erythropoietin secretion during hypoxia Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1501 - F1511. [Abstract] [Full Text] [PDF]