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Journal of Pharmacology And Experimental Therapeutics Fast Forward
First published on April 27, 2006; DOI: 10.1124/jpet.106.103465

0022-3565/06/3183-933-938$20.00
JPET 318:933-938, 2006
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PERSPECTIVES IN PHARMACOLOGY

Role of Matrix Metalloproteinases in Intestinal Inflammation

Carlos Medina, and Marek W. Radomski

School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland and Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas

Matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of MMPs (TIMPs), are produced in the gastrointestinal tract by several structural cells. The balance between MMPs and TIMPs is essential for many physiological processes in the gut. However, imbalance between MMPs and TIMPs plays an important role in the pathophysiology of diverse intestinal inflammatory conditions. We reviewed the role of the MMP/TIMP system in the pathogenesis of intestinal inflammatory diseases and pharmacologic perspectives for the use of compounds that restore the MMP/TIMP balance.

Received March 1, 2006; accepted April 24, 2006.

Address correspondence to: Dr. Marek W. Radomski, Chair of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland. E-mail: radomskm{at}tcd.ie




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