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CELLULAR AND MOLECULAR
Division of Immunology (K.K.), Division of Cellular and Molecular Pharmacology (N.E.N., C.O., L.M.F.L-L., B.O.), Department for Experimental Medical Science, Lund University, Lund, Sweden; Division of Obstetrics and Gynecology, Department of Clinical Science, Lund University, Lund, Sweden (S.H.); HeptaHelix AB (J.B., Å.B., C.O.), Malmö, Sweden; and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden (R.S., Å.N.)
Here, the ligand binding, activation, and tissue distribution of the orphan G protein-coupled receptor (GPCR) GPR92 were studied. GPR92 binds and is activated by compounds based on the lysophosphatidic acid (LPA) backbone. The binding of LPA to GPR92 was of high affinity (KD = 6.4 ± 0.9 nM) and led to an increase in both phosphoinositide hydrolysis and cAMP production. GPR92 is atypical in that it has a low sequence homology with the classic LPA1-3 receptors (21-22%). Expression of GPR92 is mainly found in heart, placenta, spleen, brain, lung, and gut. Notably, GPR92 is highly expressed in the lymphocyte compartment of the gastrointestinal tract. It is the most abundant GPCR activated by LPA found in the small intestinal intraepithelial CD8+ cytotoxic T cells.
Address correspondence to: Dr. Björn Olde, BMC A12, 22184 Lund, Sweden. E-mail: bjorn.olde{at}med.lu.se
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