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Journal of Pharmacology And Experimental Therapeutics Fast Forward
First published on November 10, 2004; DOI: 10.1124/jpet.104.076943

0022-3565/05/3131-1-7$20.00
JPET 313:1-7, 2005
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PERSPECTIVES IN PHARMACOLOGY

Ligand Discovery Using Small Molecule Microarrays

Xuezhong G. He, Guillermo Gerona-Navarro, and Samie R. Jaffrey

Department of Pharmacology, Weill Medical College, Cornell University, New York, New York

Small molecule microarrays have recently been used to identify ligands for several proteins, and several themes regarding screening strategies and limitations have emerged. In this review, some of the technical issues related to the manufacture and screening of small molecule microarrays, as well as prospects for small molecule microarrays in several areas of drug discovery and chemistry, are discussed.

Received August 31, 2004; accepted November 9, 2004.

Address correspondence to: Dr. Samie R. Jaffrey, Department of Pharmacology, Weill Medical College, Cornell University, 1300 York Avenue, Box 70, New York, NY 10021. E-mail: srj2003{at}med.cornell.edu






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