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Journal of Pharmacology And Experimental Therapeutics Fast Forward
First published on November 4, 2004; DOI: 10.1124/jpet.104.075150

0022-3565/05/3122-417-423$20.00
JPET 312:417-423, 2005
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PERSPECTIVES IN PHARMACOLOGY

Bacterial Communication ("Quorum Sensing") via Ligands and Receptors: A Novel Pharmacologic Target for the Design of Antibiotic Drugs

Robert B. Raffa, Joseph R. Iannuzzo, Diana R. Levine, Kamal K. Saeid, Rachel C. Schwartz, Nicholas T. Sucic, Oksana D. Terleckyj, and Jeffrey M. Young

Temple University School of Pharmacy, Philadelphia, Pennsylvania

The purpose of the present Perspectives is to present a synopsis of the literature on bacterial "quorum sensing" as a background for the proposal that interference with this communication system offers potential targets for the design of novel antibiotic drugs. Quorum sensing is the recently discovered chemical communication system among bacteria (both Gram-positive and -negative). It is vital for intra- and interbacterial gene regulation and for keeping bacterial colonies ("biofilms") intact, allowing resident bacteria to assume specialized roles that contribute to enhanced survival of the group. There are several processes involved in quorum sensing that are familiar to pharmacologists; i.e., specific signaling molecules bind to and activate receptors that transduce the quorum-sensing signal into intracellular second messenger responses. We highlight herein the similarity between quorum-sensing communication to ligand-receptor interactions, suggesting that inhibitor drugs could be designed using current standard pharmacologic principles. Such drugs would have novel mechanisms of action and might therefore be more effective against antibiotic-resistant strains of bacteria.

Received July 28, 2004; accepted October 25, 2004.

Address correspondence to: Dr. Robert B. Raffa, Professor of Pharmacology, Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA 19140-5101. E-mail: robert.raffa{at}temple.edu




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