QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: jpet.103.060186v1 308/3/1213    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lin, C.-H. Articles by Tseng, C.-J. Search for Related Content PubMed PubMed Citation Articles by Lin, C.-H. Articles by Tseng, C.-J.

CARDIOVASCULAR

Interactions of Carbon Monoxide and Metabotropic Glutamate Receptor Groups in the Nucleus Tractus Solitarii of Rats

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C. (C.H.L., W.C.L., M.H., C.J.T.); and Department of Physiology, National Defense Medical Center, Taipei, Taiwan, R.O.C. (C.S.T.)

Carbon monoxide has been shown to act as a neurotransmitter and neuronal messenger in the brain. Heme oxygenase catalyzes the conversion of heme to carbon monoxide and biliverdin. We have recently reported that carbon monoxide was involved in central cardiovascular regulation. Carbon monoxide modulated the baroreflex and may affect glutamatergic neurotransmission. In addition, metabotropic glutamate receptors may be coupled to the activation of heme oxygenase in the nucleus tractus solitarii of rats. The present study was designed to investigate the possible interactions of carbon monoxide and metabotropic glutamate receptor groups in the nucleus tractus solitarii. Unilateral microinjection of several agonists for metabotropic glutamate receptor groups such as (R,S)-3,5-dihydroxyphenylglycine (DHPG) (group I) (0.03 nmol), 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (APDC) (group II) (0.3 nmol), and L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) (group III) (0.3 nmol) produced a significant decrease in blood pressure and heart rate. Among the metabotropic glutamate receptor agonists, prior administration of zinc protoporphyrin IX, an inhibitor of heme oxygenase activity, significantly attenuated the cardiovascular effects of APDC and L-AP4, and failed to attenuate the cardiovascular responses of DHPG. These results indicated interactions between carbon monoxide and group II and III metabotropic glutamate receptors in central cardiovascular regulation.

Address correspondence to: Dr. Ching-Jiunn Tseng, Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Rd., Kaohsiung, Taiwan, R.O.C. E-mail: cjtseng{at}isca.vghks.gov.tw

This article has been cited by other articles:

				D. E. Stec, H. A. Drummond, and T. Vera Role of Carbon Monoxide in Blood Pressure Regulation Hypertension, March 1, 2008; 51(3): 597 - 604. [Full Text] [PDF]

				W.-Y. Ho, P.-J. Lu, M. Hsiao, H.-R. Hwang, Y.-C. Tseng, M.-H. Yen, and C.-J. Tseng Adenosine Modulates Cardiovascular Functions Through Activation of Extracellular Signal-Regulated Kinases 1 and 2 and Endothelial Nitric Oxide Synthase in the Nucleus Tractus Solitarii of Rats Circulation, February 12, 2008; 117(6): 773 - 780. [Abstract] [Full Text] [PDF]

				P. J. Mueller, C. M. Foley, H. W. Vogl, M. Hay, and E. M. Hasser Cardiovascular response to a group III mGluR agonist in NTS requires NMDA receptors Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R198 - R208. [Abstract] [Full Text] [PDF]

				H.-N. Huang, P.-J. Lu, W.-C. Lo, C.-H. Lin, M. Hsiao, and C.-J. Tseng In Situ Akt Phosphorylation in the Nucleus Tractus Solitarii Is Involved in Central Control of Blood Pressure and Heart Rate Circulation, October 19, 2004; 110(16): 2476 - 2483. [Abstract] [Full Text] [PDF]

				D. Boehning, L. Sedaghat, T. W. Sedlak, and S. H. Snyder Heme Oxygenase-2 Is Activated by Calcium-Calmodulin J. Biol. Chem., July 23, 2004; 279(30): 30927 - 30930. [Abstract] [Full Text] [PDF]

				S. W. Ryter, D. Morse, and A. M. K. Choi Carbon Monoxide: To Boldly Go Where NO Has Gone Before Sci. Signal., April 27, 2004; 2004(230): re6 - re6. [Abstract] [Full Text] [PDF]