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NEUROPHARMACOLOGY

GABA_A Receptor 1 and 2 Subunit Null Mutant Mice: Behavioral Responses to Ethanol

Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas at Austin, Austin, Texas

Mice lacking either the 1 or 2 subunit of the GABA_A receptor were tested for ethanol, saccharin, or quinine consumption, ethanol-conditioned place preference, ethanol-conditioned taste aversion, ethanol-simulated motor activity, and handling-induced seizures following chronic consumption of an ethanol liquid diet. The 1 null mutants showed decreased ethanol and saccharin consumption, increased aversion to ethanol, and a marked stimulation of motor activity after injection of ethanol. The 2 null mutants showed decreased consumption of saccharin and quinine, but not ethanol. Surprisingly, neither mutant showed marked changes in handling induced seizures before or after withdrawal of ethanol. The unique effects of deletion of these two GABA_A receptor subunits on ethanol responses are discussed in terms of the distinct changes in different populations of GABA_A receptors.

Address correspondence to: Dr. Yuri A. Blednov, Waggoner Center for Alcohol and Addiction Research, University of Texas A4800, 2500 Speedway MBB 1.124, Austin, TX 78712-1095. E-mail: yablednov{at}mail.utexas.edu

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