JPET Assistant Professor of Medicine (Clinician-Educator)

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Pharmacology And Experimental Therapeutics Fast Forward
First published on January 21, 2003; DOI: 10.1124/jpet.102.047712

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jpet.102.047712v1
305/1/385    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Inoue, K.
Right arrow Articles by Zorrilla, E. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Inoue, K.
Right arrow Articles by Zorrilla, E. P.

Vol. 305, Issue 1, 385-393, April 2003

Human Urocortin II, a Selective Agonist for the Type 2 Corticotropin-Releasing Factor Receptor, Decreases Feeding and Drinking in the Rat

Koki Inoue , Glenn R. Valdez, Teresa M. Reyes, Lindsay E. Reinhardt, Antoine Tabarin , Jean Rivier, Wylie W. Vale, Paul E. Sawchenko, George F. Koob and Eric P. Zorrilla

Department of Neuropharmacology (K.I., G.R.V., L.E.R., A.T., G.F.K., E.P.Z.), The Scripps Research Institute, La Jolla, California; Osaka City University Medical School (K.I.), Osaka, Japan; Neuronal Structure and Function (T.M.R., P.E.S.) and Peptide Biology Laboratory (J.R., W.W.V.), Salk Institute for Biological Studies, La Jolla, California; and University of Bordeaux (A.T.), Bordeaux, France

Corticotropin-releasing factor (CRF) has been hypothesized to modulate consummatory behavior through the Type 2 CRF (CRF2) receptor. However, behavioral functions subserved by the CRF2 receptor remain poorly understood. Recently, human urocortin II (hUcn II), a selective CRF2 receptor agonist, was identified. To study the effects of this neuropeptide on ingestive behavior, we examined the effects of centrally infused hUcn II (i.c.v. 0, 0.01, 0.1, 1.0, 10.0 µg) on the microstructure of nose-poke responding for food and water in nondeprived, male rats. Malaise-inducing properties of the peptide were monitored using conditioned taste aversion (CTA) testing. To identify potential sites of action, central induction of Fos protein expression was examined. hUcn II dose dependently reduced the quantity and duration of responding for food and water at doses lower (0.01-1.0 µg) than that forming a CTA (10 µg). Effects were most evident during hours 4 to 6 of the dark cycle. Meal pattern analysis showed that hUcn II potently (0.1 µg) increased the satiating value of food. Rats ate and drank smaller and shorter meals without changing meal frequency. Rats also ate more slowly. hUcn II induced Fos in regions involved in visceral sensory processing and autonomic/neuroendocrine regulation and resembling those activated by appetite suppressants. hUcn II is a promising neuropeptide for investigating the role of the CRF2 receptor in ingestive behavior.

0022-3565/03/3051-0385$07.00/0
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copyright © 2003 by The American Society for Pharmacology and Experimental Therapeutics


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Chotiwat and R. B. S. Harris
Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1762 - R1773.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. Gourcerol, L. Wang, Y. H. Wang, M. Million, and Y. Tache
Urocortins and Cholecystokinin-8 Act Synergistically to Increase Satiation in Lean But Not Obese Mice: Involvement of Corticotropin-Releasing Factor Receptor-2 Pathway
Endocrinology, December 1, 2007; 148(12): 6115 - 6123.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. P. Bakshi, S. M. Newman, S. Smith-Roe, K. A. Jochman, and N. H. Kalin
Stimulation of Lateral Septum CRF2 Receptors Promotes Anorexia and Stress-Like Behaviors: Functional Homology to CRF1 Receptors in Basolateral Amygdala
J. Neurosci., September 26, 2007; 27(39): 10568 - 10577.
[Abstract] [Full Text] [PDF]

Home page
 J PsychopharmacolHome page
L. Mattioli and M. Perfumi
Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats
J Psychopharmacol, September 1, 2007; 21(7): 742 - 750.
[Abstract] [PDF]

Home page
 J. Physiol.Home page
P. Cottone, V. Sabino, T. R. Nagy, D. V. Coscina, and E. P. Zorrilla
Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2
J. Physiol., September 1, 2007; 583(2): 487 - 504.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
L. E. O'Dell, S. A. Chen, R. T. Smith, S. E. Specio, R. L. Balster, N. E. Paterson, A. Markou, E. P. Zorrilla, and G. F. Koob
Extended Access to Nicotine Self-Administration Leads to Dependence: Circadian Measures, Withdrawal Measures, and Extinction Behavior in Rats
J. Pharmacol. Exp. Ther., January 1, 2007; 320(1): 180 - 193.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. Czimmer, M. Million, and Y. Tache
Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats
Am J Physiol Gastrointest Liver Physiol, March 1, 2006; 290(3): G511 - G518.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. T. Rademaker, V. A. Cameron, C. J. Charles, and A. M. Richards
Integrated Hemodynamic, Hormonal, and Renal Actions of Urocortin 2 in Normal and Paced Sheep: Beneficial Effects in Heart Failure
Circulation, December 6, 2005; 112(23): 3624 - 3632.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. L. Seymour, S. L. Dettloff, J. E. Jones, and G. N. Wade
Corticotropin-releasing factor receptor subtypes mediating nutritional suppression of estrous behavior in Syrian hamsters
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R418 - R423.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. C. Heinrichs and G. F. Koob
Corticotropin-Releasing Factor in Brain: A Role in Activation, Arousal, and Affect Regulation
J. Pharmacol. Exp. Ther., November 1, 2004; 311(2): 427 - 440.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
E. P. Zorrilla, L. E. Reinhardt, G. R. Valdez, K. Inoue, J. E. Rivier, W. W. Vale, and G. F. Koob
Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)2 Agonist, and Ovine CRF, a CRF1 Agonist, Differentially Alter Feeding and Motor Activity
J. Pharmacol. Exp. Ther., September 1, 2004; 310(3): 1027 - 1034.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 2003 by the American Society for Pharmacology and Experimental Therapeutics.