JPET Data Acquisition and Analysis Systems for the Life Sciences

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rodd-Henricks, Z. A.
Right arrow Articles by McBride, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rodd-Henricks, Z. A.
Right arrow Articles by McBride, W. J.

Vol. 303, Issue 3, 1216-1226, December 2002

Cocaine Is Self-Administered into the Shell but Not the Core of the Nucleus Accumbens of Wistar Rats

Zachary A. Rodd-Henricks, David L. McKinzie, Ting-Kai Li, James M. Murphy and William J. McBride

Institute of Psychiatric Research and Department of Psychiatry (Z.A.R.-H., D.L.M., J.M.M., W.J.M.), and Departments of Medicine (T.-K.L.) and Biochemistry (W.J.M.), Indiana University School of Medicine, Indianapolis, Indiana; and Department of Psychology (J.M.M.), Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana

The rewarding properties of cocaine have been postulated to be regulated, in part, by the mesolimbic dopamine system. However, the possibility that the rewarding properties of cocaine are mediated by direct activation of this system has yielded contradictory findings. The intracranial self-administration technique is used to identify specific brain regions involved in the initiation of response-contingent behaviors for the delivery of a reinforcer. The present study assessed whether adult Wistar rats would self-administer cocaine directly into the nucleus accumbens shell (AcbSh) and core (AcbC). For each subregion, subjects were placed in standard two-lever operant chambers and randomly assigned to one of five groups for each site that were given either artificial cerebrospinal fluid (aCSF), or 400, 800, 1200, or 1600 pmol of cocaine/100 nl to self-administer. The data indicate that rats with placements within the AcbSh readily self-administered 800 to 1600 pmol of cocaine/100 nl and responded significantly more on the active than inactive lever. These subjects also decreased responding on the active lever when aCSF was substituted for cocaine and reinstated responding on the active lever when cocaine was reintroduced. Coinfusion of the D2-like receptor antagonist sulpiride inhibited cocaine self-infusion in the AcbSh. In contrast to the AcbSh data, rats failed to self-administer any tested dose of cocaine into the AcbC or areas ventral to the AcbSh. These findings suggest that the AcbSh is a neuroanatomical substrate for the reinforcing effects of cocaine and that activation of D2-like receptors is involved.

0022-3565/02/3033-1216$07.00/0
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copyright © 2002 by The American Society for Pharmacology and Experimental Therapeutics


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
L. H. L. Sellings, L. E. McQuade, and P. B. S. Clarke
Evidence for Multiple Sites within Rat Ventral Striatum Mediating Cocaine-Conditioned Place Preference and Locomotor Activation
J. Pharmacol. Exp. Ther., June 1, 2006; 317(3): 1178 - 1187.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. J. M. J. Vanderschuren, P. Di Ciano, and B. J. Everitt
Involvement of the Dorsal Striatum in Cue-Controlled Cocaine Seeking
J. Neurosci., September 21, 2005; 25(38): 8665 - 8670.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Ikemoto, M. Qin, and Z.-H. Liu
The Functional Divide for Primary Reinforcement of D-Amphetamine Lies between the Medial and Lateral Ventral Striatum: Is the Division of the Accumbens Core, Shell, and Olfactory Tubercle Valid?
J. Neurosci., May 18, 2005; 25(20): 5061 - 5065.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
Z. A. Rodd, R. L. Bell, K. A. Kuc, Y. Zhang, J. M. Murphy, and W. J. McBride
Intracranial Self-Administration of Cocaine within the Posterior Ventral Tegmental Area of Wistar Rats: Evidence for Involvement of Serotonin-3 Receptors and Dopamine Neurons
J. Pharmacol. Exp. Ther., April 1, 2005; 313(1): 134 - 145.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. A. Rodd, R. I. Melendez, R. L. Bell, K. A. Kuc, Y. Zhang, J. M. Murphy, and W. J. McBride
Intracranial Self-Administration of Ethanol within the Ventral Tegmental Area of Male Wistar Rats: Evidence for Involvement of Dopamine Neurons
J. Neurosci., February 4, 2004; 24(5): 1050 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Ikemoto
Involvement of the Olfactory Tubercle in Cocaine Reward: Intracranial Self-Administration Studies
J. Neurosci., October 15, 2003; 23(28): 9305 - 9311.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
U. E. Ghitza, A. T. Fabbricatore, V. Prokopenko, A. P. Pawlak, and M. O. West
Persistent Cue-Evoked Activity of Accumbens Neurons after Prolonged Abstinence from Self-Administered Cocaine
J. Neurosci., August 13, 2003; 23(19): 7239 - 7245.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Filip and K. A. Cunningham
Hyperlocomotive and Discriminative Stimulus Effects of Cocaine Are Under the Control of Serotonin2C (5-HT2C) Receptors in Rat Prefrontal Cortex
J. Pharmacol. Exp. Ther., August 1, 2003; 306(2): 734 - 743.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 2002 by the American Society for Pharmacology and Experimental Therapeutics.