JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sonnewald, U.
Right arrow Articles by Aschner, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sonnewald, U.
Right arrow Articles by Aschner, M.

Vol. 301, Issue 1, 1-6, April 2002

Pharmacology and Toxicology of Astrocyte-Neuron Glutamate Transport and Cycling

Ursula Sonnewald, Hong Qu and Michael Aschner

Department of Clinical Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway (U.S., H.Q.); and Department of Physiology and Pharmacology, and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina (M.A.)

The interaction between astrocytes and neurons is examined from the standpoint of glutamate neurotoxicity. The review details 1) the distribution of glutamate transporters on astrocytes and neurons, provoking a reformulation of the interdependence between these two cell types in removing extracellular glutamate and preventing excitotoxic injury; 2) the potential involvement of aberrant glutamate transporter function in the etiology of neuropathological conditions; 3) the role of astrocyte-neuron interaction in widely divergent aspects of brain energetics; 4) the role of astrocytes in the process of glutamate recycling within the context of anesthetic treatment with pentobarbital and thiopental.

0022-3565/02/3011-0001$03.00/0
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copyright © 2002 by The American Society for Pharmacology and Experimental Therapeutics


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
A. D. Kraft, D. A. Johnson, and J. A. Johnson
Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation by tert-Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult
J. Neurosci., February 4, 2004; 24(5): 1101 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. Tao, H.-R. Liu, E. Gao, Z.-P. Teng, B. L. Lopez, T. A. Christopher, X.-L. Ma, I. Batinic-Haberle, R. N. Willette, E. H. Ohlstein, et al.
Antioxidative, Antinitrative, and Vasculoprotective Effects of a Peroxisome Proliferator-Activated Receptor-{gamma} Agonist in Hypercholesterolemia
Circulation, December 2, 2003; 108(22): 2805 - 2811.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-M. Lee, M. J. Calkins, K. Chan, Y. W. Kan, and J. A. Johnson
Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis
J. Biol. Chem., March 28, 2003; 278(14): 12029 - 12038.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Carnesecchi, A. Bradaia, B. Fischer, D. Coelho, M. Scholler-Guinard, F. Gosse, and F. Raul
Perturbation by Geraniol of Cell Membrane Permeability and Signal Transduction Pathways in Human Colon Cancer Cells
J. Pharmacol. Exp. Ther., November 1, 2002; 303(2): 711 - 715.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Constantinescu, A. S. Gordon, and I. Diamond
cAMP-dependent Protein Kinase Types I and II Differentially Regulate cAMP Response Element-mediated Gene Expression. IMPLICATIONS FOR NEURONAL RESPONSES TO ETHANOL
J. Biol. Chem., May 17, 2002; 277(21): 18810 - 18816.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
M. Yan, L. T. Webster Jr., and J. L. Blumer
3-O-Methyldobutamine, a Major Metabolite of Dobutamine in Humans
Drug Metab. Dispos., May 1, 2002; 30(5): 519 - 524.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 2002 by the American Society for Pharmacology and Experimental Therapeutics.