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Journal of Pharmacology And Experimental Therapeutics, Vol. 30, Issue 1, 31-37, 1926
Copyright © 1926 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON STRYCHNIN

GRACE NEWMAN 1

1 From the Department of Pharmacology of Cornell University Medical College, New York City

1. The injection of 0.000,02 mgm. strychnin (corresponding to 0.0009 mgm. per kilogram) into the spinal canal of common grass frog caused hyperexcitability, and a dose of 0.000,04 mgm. (corresponding to 0.002 mgm. per kilogram) caused tetanus in another frog.

2. Tetanus was also caused by the injection into the spinal canal of a trace of strychnin in an extract of tissues containing several hundred times as much of the tissue extract as of the strychnin.

3. Only traces of strychnin were present in the urine 96 hours after the oral administration of a dose of 4.68 mgm. (6 mgm. of the sulphate) to each of three adults. Strychnin was detected in the urine of one, but not in that of either of the other two, after 120 hours.

Submitted on August 3, 1926






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Copyright © 1926 by the American Society for Pharmacology and Experimental Therapeutics.