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Vol. 299, Issue 3, 818-824, December 2001
Department of Pharmacology and Molecular Cardiobiology Program,
Boyer Center for Molecular Medicine, Yale University School of
Medicine, New Haven, Connecticut
Endothelial nitric oxide synthase (eNOS) is important for
cardiovascular homeostasis, vessel remodeling, and angiogenesis. Given
the impact of endothelium- derived nitric oxide (NO) in vascular
biology, much work in the past several years has focused on the control
of NO synthesis by regulatory proteins that influence its function.
Indeed calcium-activated calmodulin is important for regulation of NOS
activity. Herein we discuss why other proteins, in addition to
calmodulin, are necessary for eNOS regulation and summarize the biology
of negative and positive regulators of eNOS function in vitro, in
cells, and in blood vessels.
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R. Stocker and J. F. Keaney Jr. Role of Oxidative Modifications in Atherosclerosis Physiol Rev, October 1, 2004; 84(4): 1381 - 1478. [Abstract] [Full Text] [PDF]
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 C. Richard, J. Gao, B. LaFleur, B. W. Christman, J. Anderson, N. Brown, and J. Reese Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R652 - R660. [Abstract] [Full Text] [PDF]
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M. T Weis, J. L Crumley, L. H Young, and J. N Stallone Inhibiting long chain fatty Acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endothelium Cardiovasc Res, August 1, 2004; 63(2): 338 - 346. [Abstract] [Full Text] [PDF]
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D. Fulton, R. Babbitt, S. Zoellner, J. Fontana, L. Acevedo, T. J. McCabe, Y. Iwakiri, and W. C. Sessa Targeting of Endothelial Nitric-oxide Synthase to the Cytoplasmic Face of the Golgi Complex or Plasma Membrane Regulates Akt- Versus Calcium-dependent Mechanisms for Nitric Oxide Release J. Biol. Chem., July 16, 2004; 279(29): 30349 - 30357. [Abstract] [Full Text] [PDF]
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J.-P. Gratton, P. Bernatchez, and W. C. Sessa Caveolae and Caveolins in the Cardiovascular System Circ. Res., June 11, 2004; 94(11): 1408 - 1417. [Abstract] [Full Text] [PDF]
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C. D. Fike, J. L. Aschner, Y. Zhang, and M. R. Kaplowitz Impaired NO signaling in small pulmonary arteries of chronically hypoxic newborn piglets Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1244 - L1254. [Abstract] [Full Text] [PDF]
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 W. C. Sessa eNOS at a glance J. Cell Sci., May 15, 2004; 117(12): 2427 - 2429. [Full Text] [PDF]
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 A. W. Cohen, B. Razani, W. Schubert, T. M. Williams, X. B. Wang, P. Iyengar, D. L. Brasaemle, P. E. Scherer, and M. P. Lisanti Role of Caveolin-1 in the Modulation of Lipolysis and Lipid Droplet Formation Diabetes, May 1, 2004; 53(5): 1261 - 1270. [Abstract] [Full Text] [PDF]
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M. Bucci, F. Roviezzo, V. Brancaleone, M. I. Lin, A. Di Lorenzo, C. Cicala, A. Pinto, W. C. Sessa, S. Farneti, S. Fiorucci, et al. Diabetic Mouse Angiopathy Is Linked to Progressive Sympathetic Receptor Deletion Coupled to an Enhanced Caveolin-1 Expression Arterioscler. Thromb. Vasc. Biol., April 1, 2004; 24(4): 721 - 726. [Abstract] [Full Text] [PDF]
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S. C. Tai, G. B. Robb, and P. A. Marsden Endothelial Nitric Oxide Synthase: A New Paradigm for Gene Regulation in the Injured Blood Vessel Arterioscler. Thromb. Vasc. Biol., March 1, 2004; 24(3): 405 - 412. [Abstract] [Full Text]
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A. Papapetropoulos, D. Fulton, M. I. Lin, J. Fontana, T. J. McCabe, S. Zoellner, G. Garcia-Cardena, Z. Zhou, J.-P. Gratton, and W. C. Sessa Vanadate Is a Potent Activator of Endothelial Nitric-Oxide Synthase: Evidence for the Role of the Serine/Threonine Kinase Akt and the 90-kDa Heat Shock Protein Mol. Pharmacol., February 1, 2004; 65(2): 407 - 415. [Abstract] [Full Text] [PDF]
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K. S. Aulak, T. Koeck, J. W. Crabb, and D. J. Stuehr Dynamics of protein nitration in cells and mitochondria Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H30 - H38. [Abstract] [Full Text] [PDF]
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S. Liu, R. T. Premont, C. D. Kontos, J. Huang, and D. C. Rockey Endothelin-1 Activates Endothelial Cell Nitric-oxide Synthase via Heterotrimeric G-protein {beta}{gamma} Subunit Signaling to Protein Kinase B/Akt J. Biol. Chem., December 12, 2003; 278(50): 49929 - 49935. [Abstract] [Full Text] [PDF]
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R. D. Minshall, W. C. Sessa, R. V. Stan, R. G. W. Anderson, and A. B. Malik Caveolin regulation of endothelial function Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1179 - L1183. [Abstract] [Full Text] [PDF]
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M. I. Lin, D. Fulton, R. Babbitt, I. Fleming, R. Busse, K. A. Pritchard Jr., and W. C. Sessa Phosphorylation of Threonine 497 in Endothelial Nitric-oxide Synthase Coordinates the Coupling of L-Arginine Metabolism to Efficient Nitric Oxide Production J. Biol. Chem., November 7, 2003; 278(45): 44719 - 44726. [Abstract] [Full Text] [PDF]
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 R. van Haperen, C. Cheng, B. M. E. Mees, E. van Deel, M. de Waard, L. C.A. van Damme, T. van Gent, T. van Aken, R. Krams, D. J. Duncker, et al. Functional Expression of Endothelial Nitric Oxide Synthase Fused to Green Fluorescent Protein in Transgenic Mice Am. J. Pathol., October 1, 2003; 163(4): 1677 - 1686. [Abstract] [Full Text] [PDF]
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M. Yoshida and Y. Xia Heat Shock Protein 90 as an Endogenous Protein Enhancer of Inducible Nitric-oxide Synthase J. Biol. Chem., September 19, 2003; 278(38): 36953 - 36958. [Abstract] [Full Text] [PDF]
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Y. C. Boo and H. Jo Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases Am J Physiol Cell Physiol, September 1, 2003; 285(3): C499 - C508. [Abstract] [Full Text] [PDF]
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H. Hendrickson, S. Chatterjee, S. Cao, M. M. Ruiz, W. C. Sessa, and V. Shah Influence of caveolin on constitutively activated recombinant eNOS: insights into eNOS dysfunction in BDL rat liver Am J Physiol Gastrointest Liver Physiol, August 8, 2003; 285(3): G652 - G660. [Abstract] [Full Text] [PDF]
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Y. Su, S. Edwards-Bennett, M. R. Bubb, and E. R. Block Regulation of endothelial nitric oxide synthase by the actin cytoskeleton Am J Physiol Cell Physiol, June 1, 2003; 284(6): C1542 - C1549. [Abstract] [Full Text] [PDF]
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M. Pelat, C. Dessy, P. Massion, J.-P. Desager, O. Feron, and J.-L. Balligand Rosuvastatin Decreases Caveolin-1 and Improves Nitric Oxide-Dependent Heart Rate and Blood Pressure Variability in Apolipoprotein E-/- Mice In Vivo Circulation, May 20, 2003; 107(19): 2480 - 2486. [Abstract] [Full Text] [PDF]
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S. Wedgwood, C. J. Mitchell, J. R. Fineman, and S. M. Black Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1 Am J Physiol Lung Cell Mol Physiol, April 1, 2003; 284(4): L650 - L662. [Abstract] [Full Text] [PDF]
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