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Vol. 299, Issue 3, 818-824, December 2001
Department of Pharmacology and Molecular Cardiobiology Program,
Boyer Center for Molecular Medicine, Yale University School of
Medicine, New Haven, Connecticut
Endothelial nitric oxide synthase (eNOS) is important for
cardiovascular homeostasis, vessel remodeling, and angiogenesis. Given
the impact of endothelium- derived nitric oxide (NO) in vascular
biology, much work in the past several years has focused on the control
of NO synthesis by regulatory proteins that influence its function.
Indeed calcium-activated calmodulin is important for regulation of NOS
activity. Herein we discuss why other proteins, in addition to
calmodulin, are necessary for eNOS regulation and summarize the biology
of negative and positive regulators of eNOS function in vitro, in
cells, and in blood vessels.
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 J. Zheng, Y. |
