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Vol. 298, Issue 3, 873-878, September 2001
Department of Cancer Biology, Abramson Family Cancer Research
Institute, University of Pennsylvania, Philadelphia, Pennsylvania
Cells of multicellular organisms require extracellular signals to
survive. Numerous studies have implicated a variety of intracellular signaling pathways, including PI-3 kinase/Akt, Ras/mitogen-activated protein kinase, and Jak/signal transducers and activators of
transcription, as effectors of these extracellular trophic
factors. Binding of growth factors to their respective receptors
results in the activation of individual and combined pathways resulting
in pleiotropic effects on cellular biochemistry. Over the past decade,
investigation of these pathways has provided insight into the mechanism
of cell survival and apoptosis itself. The results of these studies are providing new clues for therapeutic intervention in human disease. In
this review, we focus on advances in our current understanding of the
receptor signaling pathways that regulate apoptosis. Implications for
the pharmacological manipulation of apoptosis in the treatment of
cancer are also discussed.
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