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Vol. 298, Issue 2, 395-402, August 2001
Division of Pharmaceutical Sciences, College of Pharmacy,
University of Kentucky, Lexington, Kentucky
Neuronal nicotinic acetylcholine receptors are distributed extensively
throughout the central and peripheral nervous systems. Currently, there
is great interest in determining the structural and functional
diversity of these receptors, and in developing subtype-selective
agonists that have potential as therapeutic agents for neuropathology
and disease. However, relatively little attention has been focused on
the development of subtype-selective nicotinic receptor antagonists.
Such antagonists would be beneficial for establishing the role of
specific nicotinic receptor subtypes in physiological function and for
unraveling the complexities of neuronal nicotinic receptor function.
Furthermore, these subtype-selective antagonists may also prove to be
beneficial in the treatment of neuropathology and disease. The current
perspective summarizes the research that has been carried out with both
classical competitive antagonists and more recently developed
competitive nicotinic receptor antagonists.
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