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Vol. 298, Issue 1, 148-155, July 2001
Department of Psychiatry, University of California San Diego, La
Jolla, California
Several reports describe substantive behavioral differences between
strains of mice both at baseline and in response to pharmacological manipulations. For example, mouse strain differences have been reported
in prepulse inhibition (PPI) and patterns of locomotor activity, two
behavioral processes that are altered by dopamine (DA) agonists such as
amphetamine. Here, we characterized acoustic and tactile startle
reactivity, acoustic PPI, and both the amounts and spatial patterns of
locomotor activity in C57BL/6J, 129SvEv (129S6), and 129SvJ (129X1)
mice at baseline and in amphetamine dose-response studies. Because
hearing loss is common in numerous strains of mice, we also assessed
cross-modal PPI using a light prepulse with an airpuff startle
stimulus. The results establish that these three inbred strains of mice
display both intra- and cross-modal PPI, and that amphetamine decreases
PPI and startle reactivity in a dose-, sensory modality-, and
strain-specific manner. Furthermore, the amount of locomotor activity
and the spatial pattern of motor sequences are altered differentially after treatment with amphetamine in C57BL/6J and 129X1 mice, but not in
129S6 mice. Given that amphetamine releases presynaptic DA, these
findings are consistent with the role of DA in the modulation of PPI
and motor patterns in mice. These findings highlight the importance of
selecting appropriate strains of mice for behavioral, pharmacological,
and genetic studies.
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