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Vol. 295, Issue 1, 1-9, October 2000
Department of Pediatrics, Section of Hematology/Oncology, Herman B. Wells Center for Pediatric Research and Department of Biochemistry and
Molecular Biology, Indiana University School of Medicine, Indianapolis,
Indiana
The area of mammalian DNA repair and its relationship to cancer and
therapeutic approaches is rapidly growing, both through the studies of
basic mechanisms and in the use of this knowledge for translational
applications. We have attempted to briefly and succinctly cover the
four pathways of mammalian DNA repair, which are: direct reversal,
mismatch, nucleotide excision, and base excision repair. We have also
tried to identify and reference results in the literature relating the
various repair pathways to cellular resistance following
chemotherapeutic treatments and to provide some potential direction
whereby laboratory results may be applicable to clinical therapeutics,
particularly for cancer treatments.
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