![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 294, Issue 2, 680-687, August 2000
Harvard Medical School, New England Regional Primate Research
Center, Southborough, Massachusetts
Dopaminergic mechanisms are thought to be critical in mediating relapse
to cocaine-seeking behavior. This study examined the different roles of
D1- and D2-like receptor mechanisms in the relapse process. Squirrel
monkeys were given extended histories of i.v. cocaine
self-administration under conditions in which responding was maintained
jointly by response-contingent cocaine injections and a cocaine-paired
visual stimulus (second-order schedule). Responding was then
extinguished by substituting saline for cocaine injections and omitting
presentations of the cocaine-paired stimulus. Subsequently,
noncontingent priming injections of cocaine combined with restoration
of the cocaine-paired stimulus induced dose-dependent reinstatement of
drug-seeking behavior, with response rates approaching those maintained
by active cocaine self-administration. The priming effects of cocaine
were attenuated by several D1- and D2-like receptor antagonists and low
efficacy agonists but not by the D3-preferring antagonists UH 232 and
AJ-76. The priming effects of cocaine were mimicked by the D2-like
receptor agonists R(
)-propylnorapomorphine
hydrochloride (NPA) and quinpirole, less consistently by 7-OH-DPAT, and
not by the D1-like receptor agonists SKF-81297 and SKF-82958, the
D3-preferring agonist PD-128,907, or any low efficacy agonist.
Cotreatment with NPA, PD-128,907, and 7-OH-DPAT did not alter
reinstatement of drug-seeking behavior induced by a maximally effective
priming dose of cocaine, whereas cotreatment with D1-like receptor
agonists attenuated the priming effects of cocaine. The results suggest
that D1- and D2-like receptors play fundamentally different roles in
the relapse process. Although stimulation of D2-like, but probably not
D3-like, receptors appears necessary for induction of relapse, either
stimulation or blockade of D1-like receptors appears to be inhibitory
with respect to relapse.
This article has been cited by other articles:
|
|
 |
|
  S. B. Caine, M. Thomsen, K. I. Gabriel, J. S. Berkowitz, L. H. Gold, G. F. Koob, S. Tonegawa, J. Zhang, and M. Xu Lack of Self-Administration of Cocaine in Dopamine D1 Receptor Knock-Out Mice J. Neurosci., November 28, 2007; 27(48): 13140 - 13150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Aragona and Z. Wang Opposing Regulation of Pair Bond Formation by cAMP Signaling within the Nucleus Accumbens Shell J. Neurosci., November 28, 2007; 27(48): 13352 - 13356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. T. Collins and J. H. Woods Drug and Reinforcement History as Determinants of the Response-Maintaining Effects of Quinpirole in the Rat J. Pharmacol. Exp. Ther., November 1, 2007; 323(2): 599 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Valdez, D. M. Platt, J. K. Rowlett, D. Ruedi-Bettschen, and R. D. Spealman {kappa} Agonist-Induced Reinstatement of Cocaine Seeking in Squirrel Monkeys: A Role for Opioid and Stress-Related Mechanisms J. Pharmacol. Exp. Ther., November 1, 2007; 323(2): 525 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Martinez, R. Narendran, R. W. Foltin, M. Slifstein, D.-R. Hwang, A. Broft, Y. Huang, T. B. Cooper, M. W. Fischman, H. D. Kleber, et al. Amphetamine-Induced Dopamine Release: Markedly Blunted in Cocaine Dependence and Predictive of the Choice to Self-Administer Cocaine Am J Psychiatry, April 1, 2007; 164(4): 622 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gyertyan, B. Kiss, K. Gal, I. Laszlovszky, A. Horvath, L. I. Gemesi, K. Saghy, G. Pasztor, M. Zajer, M. Kapas, et al. Effects of RGH-237 [N-{4-[4-(3-Aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an Orally Active, Selective Dopamine D3 Receptor Partial Agonist in Animal Models of Cocaine Abuse J. Pharmacol. Exp. Ther., March 1, 2007; 320(3): 1268 - 1278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, L. Zhang, H. Jiao, Q. Zhang, D. Zhang, D. Lou, J. L. Katz, and M. Xu c-Fos Facilitates the Acquisition and Extinction of Cocaine-Induced Persistent Changes J. Neurosci., December 20, 2006; 26(51): 13287 - 13296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-W. Lee, Y. Kim, A. M. Kim, K. Helmin, A. C. Nairn, and P. Greengard Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens PNAS, February 28, 2006; 103(9): 3399 - 3404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lee, D. M. Platt, J. K. Rowlett, A. S. Adewale, and R. D. Spealman Attenuation of Behavioral Effects of Cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in Squirrel Monkeys: Comparison with Dizocilpine J. Pharmacol. Exp. Ther., March 1, 2005; 312(3): 1232 - 1240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gasior, C. A. Paronis, and J. Bergman Modification by Dopaminergic Drugs of Choice Behavior under Concurrent Schedules of Intravenous Saline and Food Delivery in Monkeys J. Pharmacol. Exp. Ther., January 1, 2004; 308(1): 249 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Deroche-Gamonet, I. Sillaber, B. Aouizerate, R. Izawa, M. Jaber, S. Ghozland, C. Kellendonk, M. Le Moal, R. Spanagel, G. Schutz, et al. The Glucocorticoid Receptor as a Potential Target to Reduce Cocaine Abuse J. Neurosci., June 1, 2003; 23(11): 4785 - 4790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Vorel, C. R. Ashby Jr, M. Paul, X. Liu, R. Hayes, J. J. Hagan, D. N. Middlemiss, G. Stemp, and E. L. Gardner Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats J. Neurosci., November 1, 2002; 22(21): 9595 - 9603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-K. Park, A. A. Bari, A. R. Jey, S. M. Anderson, R. D. Spealman, J. K. Rowlett, and R. C. Pierce Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens J. Neurosci., April 1, 2002; 22(7): 2916 - 2925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Shalev, J. W. Grimm, and Y. Shaham Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review Pharmacol. Rev., March 1, 2002; 54(1): 1 - 42. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
