Endocannabinoids and Vascular Function

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Vol. 294, Issue 1, 27-32, July 2000

Endocannabinoids and Vascular Function¹

Cecilia J. Hillard

Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin

Marijuana is used by humans for its psychoactive and medicinal effects. The active constituents of marijuana, the cannabinoids,exert effects via a G protein-coupled receptor, CB₁. Two arachidonicacid analogs, N-arachidonylethanolamine and 2-arachidonylglycerolare hypothesized to function as endogenous ligands of the CB₁receptor. The cannabinoids exert significant vascular effectsin humans and laboratory animals. In particular, the cannabinoidsproduce vasodilation and hypotension. The possible mechanismsfor these effects are inhibition of transmitter release from sympatheticnerve terminals, direct effects on vascular smooth muscle cells,and effects on endothelial cell function. The data regarding theseeffects of the cannabinoids and possible sources of endocannabinoidligands in the vasculature are the subjects of thisreview.

¹ The author was supported by National Institutes of Health Grants DA09155 and DA08098 during the writing of thisreview.

0022-3565/00/2941-0027$03.00/0
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copyright © 2000 by The American Society for Pharmacology and Experimental Therapeutics

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Endocannabinoids and Vascular Function1

Endocannabinoids and Vascular Function¹

				S. Mukhopadhyay, B. M. Chapnick, and A. C. Howlett Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2046 - H2054. [Abstract] [Full Text] [PDF]