![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 294, Issue 1, 230-238, July 2000
Department of Pharmacology, Georgetown University Medical
Center, Washington, DC
The purpose of this study was to investigate the effect of
microinjection of nicotine and nicotinic receptor antagonists into the
dorsal motor nucleus of the vagus (DMV) or medial subnucleus of the
tractus solitarius (mNTS) on intragastric (IGP) and arterial blood
pressures (BP) in anesthetized rats. Nicotine microinjected into the
DMV (10-300 pmol) produced dose-related increases in IGP
(ED50 = 89 pmol); no significant changes were noted
for BP. Ipsilateral vagotomy abolished nicotine-induced increases in
IGP. Nicotine microinjected into the mNTS in a dose range of 0.1 to 300 pmol produced dose-related decreases in IGP (ED50 = 0.6 pmol) and BP (ED50 = 5.4 pmol). Bilateral vagotomy
abolished nicotine-induced decreases in IGP while having no effect on
BP. In rats treated with daily s.c. injections of nicotine (0.8 mg/kg
of base) for 10 days, microinjections of nicotine into the DMV produced
similar increases in IGP. BP responses from the mNTS were not affected by chronic treatment. However, nicotine microinjections into the mNTS
no longer produced a decrease in IGP in these chronically treated
animals. 
-Bungarotoxin (100 pmol) significantly blocked nicotine-evoked increases in IGP from the DMV while having no effect on
nicotine-induced responses elicited from the mNTS. Hexamethonium (10 and 100 pmol) microinjected into the mNTS dose-dependently blocked
nicotine-induced effects but did not interfere with the action of
nicotine at the DMV. Our data indicate that nicotine-induced changes in
IGP result from nicotine acting at two sites, the DMV and mNTS; and
that at least three different nicotinic receptors in the dorsal medulla
oblongata can influence gastrointestinal and cardiovascular function.
This article has been cited by other articles:
|
|
 |
|
  M. A. Herman, M. T. Cruz, N. Sahibzada, J. Verbalis, and R. A. Gillis GABA signaling in the nucleus tractus solitarius sets the level of activity in dorsal motor nucleus of the vagus cholinergic neurons in the vagovagal circuit Am J Physiol Gastrointest Liver Physiol, January 1, 2009; 296(1): G101 - G111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Zhou, Y.-X. Lu, H. Yao, and C. Owyang Spatial organization of neurons in the dorsal motor nucleus of the vagus synapsing with intragastric cholinergic and nitric oxide/VIP neurons in the rat Am J Physiol Gastrointest Liver Physiol, May 1, 2008; 294(5): G1201 - G1209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Niedringhaus, P. G. Jackson, S. R. T. Evans, J. G. Verbalis, R. A. Gillis, and N. Sahibzada Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus tone Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R121 - R131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Cruz, E. C. Murphy, N. Sahibzada, J. G. Verbalis, and R. A. Gillis A reevaluation of the effects of stimulation of the dorsal motor nucleus of the vagus on gastric motility in the rat Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R291 - R307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ferreira Jr., N. Sahibzada, M. Shi, M. Niedringhaus, M. R. Wester, A. R. Jones, J. G. Verbalis, and R. A. Gillis Hindbrain chemical mediators of reflex-induced inhibition of gastric tone produced by esophageal distension and intravenous nicotine Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1482 - R1495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shi, A. R. Jones, M. Ferreira Jr, N. Sahibzada, R. A. Gillis, and J. G. Verbalis Glucose does not activate nonadrenergic, noncholinergic inhibitory neurons in the rat stomach Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R742 - R750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Grabauskas, S.-Y. Zhou, S. Das, Y. Lu, C. Owyang, and H. C Moises Prolactin-releasing peptide affects gastric motor function in rat by modulating synaptic transmission in the dorsal vagal complex J. Physiol., December 15, 2004; 561(3): 821 - 839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shi, A. R. Jones, M. S. Niedringhaus, R. J. Pearson, A. M. Biehl, M. Ferreira Jr., N. Sahibzada, J. G. Verbalis, and R. A. Gillis Glucose acts in the CNS to regulate gastric motility during hypoglycemia Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1192 - R1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Wasserman, M. Ferreira Jr., N. Sahibzada, Y. M. Hernandez, and R. A. Gillis GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2002; 283(6): R1423 - R1441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ferreira Jr, N. Sahibzada, M. Shi, W. Panico, M. Niedringhaus, A. Wasserman, K. J. Kellar, J. Verbalis, and R. A. Gillis CNS Site of Action and Brainstem Circuitry Responsible for the Intravenous Effects of Nicotine on Gastric Tone J. Neurosci., April 1, 2002; 22(7): 2764 - 2779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miampamba, H. Yang, K. A. Sharkey, and Y. Tache Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious rats Am J Physiol Gastrointest Liver Physiol, May 1, 2001; 280(5): G979 - G991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ferreira, S. N. Ebert, D. C. Perry, R. P. Yasuda, C. M. Baker, M. I. Dávila-García, K. J. Kellar, and R. A. Gillis Evidence of a Functional alpha 7-Neuronal Nicotinic Receptor Subtype Located on Motoneurons of the Dorsal Motor Nucleus of the Vagus J. Pharmacol. Exp. Ther., April 13, 2001; 296(2): 260 - 269. [Abstract] [Full Text]
|
|
 |
 |
 |
|
 |
 |
 |
