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Vol. 290, Issue 2, 740-747, August 1999
-Ethinyl Estradiol Induces Pattern of
Uterine Gene Expression Similar to Endogenous Estrogen
17
-Estradiol1
Department of Integrative Biology, Pharmacology, and Physiology,
The University of Texas Medical School at Houston, Houston, Texas
17
-Ethinyl estradiol is one of most widely prescribed estrogens. We
compared the effects of this synthetic estrogen to those of the
endogenous ovarian hormone 17
-estradiol on the expression of four
estrogen-inducible genes in the rat uterus. The genes examined include
c-fos, c-jun, vascular endothelial growth
factor, and creatine kinase B, which are all known to be primary
responses to estrogen administration. Both estrogens induced the four
target genes with similar time courses and produced the same pattern of
cell-specific expression of c-fos and vascular
endothelial growth factor in the uterine epithelium and stroma,
respectively. Dose-response studies established that the potency and
efficacy of both estrogens in the uterus were the same for all four
hormone-regulated genes. These studies suggest that 17-ethinyl and
17-estradiol produce similar if not identical patterns of gene
expression in the uterus.
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