JPET Assistant Professor of Medicine (Clinician-Educator)

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eduardo da Silva-Santos, J.
Right arrow Articles by Assreuy, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eduardo da Silva-Santos, J.
Right arrow Articles by Assreuy, J.

Vol. 290, Issue 1, 380-387, July 1999

Long-Lasting Changes of Rat Blood Pressure to Vasoconstrictors and Vasodilators Induced by Nitric Oxide Donor Infusion: Involvement of Potassium Channels1

José Eduardo da Silva-Santos and Jamil Assreuy

Department of Pharmacology, Universidade Federal de Santa Catarina, SC, Brazil

We investigated the effects of the exposure of the rat vascular system to nitric oxide (NO), using infusion of either NO donor sodium nitroprusside (SNP) or S-nitroso-acetyl-DL-penicillamine (SNAP) on mean arterial pressure (MAP) responses to vasoconstrictors (phenylephrine, angiotensins I and II) and to vasodilators (bradykinin, acetylcholine, SNP, and iloprost). SNP (250 nmol/kg/ min) or SNAP (85 nmol/kg/min) infused for 30 min decreased MAP by 40 to 60 mm Hg. MAP returned to normal levels 5 to 10 min after the end of infusion. After infusion of SNP or SNAP the effects of phenylephrine, angiotensin I, and angiotensin II were reduced by 40 to 80%, whereas the responses to bradykinin or acetylcholine were enhanced by 50 to 80%. These changes in vascular responsiveness persisted for at least 24 h after the SNP infusion. Pretreatment with either tetraethylammonium (360 µmol/kg) or 4-aminopyridine (4-AP; 1 µmol/kg) did not alter the effects of phenylephrine or bradykinin in control animals, but prevented SNP-induced changes in responsiveness to phenylephrine or bradykinin. On the other hand, administration of tetraethylammonium, even 24 h after SNP infusion, reversed hyporesponsiveness to phenylephrine, whereas 4-AP was ineffective. Tetraethylammonium and 4-AP did not alter the increased responses to bradykinin. Glibenclamide was without effect in any situation. These results indicate that NO-induced changes on vascular responsiveness to vasoconstrictors and vasodilators are much more profound and long-lasting than described previously and that the effects of NO appear to be, at least in part, mediated by persistent activation of a tetraethylammonium-sensitive population of K+ channels.

0022-3565/99/2901-0380$03.00/0
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copyright © 1999 by The American Society for Pharmacology and Experimental Therapeutics


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. L. Atkins, B. W. Day, M. T. Handrigan, Z. Zhang, M. B. Pamnani, and N. V. Gorbunov
Brisk production of nitric oxide and associated formation of S-nitrosothiols in early hemorrhage
J Appl Physiol, April 1, 2006; 100(4): 1267 - 1277.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. L. Alencar, I. Lobysheva, K. Chalupsky, M. Geffard, F. Nepveu, J.-C. Stoclet, and B. Muller
S-Nitrosating Nitric Oxide Donors Induce Long-Lasting Inhibition of Contraction in Isolated Arteries
J. Pharmacol. Exp. Ther., October 1, 2003; 307(1): 152 - 159.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
J. L. Alencar, I. Lobysheva, M. Geffard, M. Sarr, C. Schott, V. B. Schini-Kerth, F. Nepveu, J.-C. Stoclet, and B. Muller
Role of S-Nitrosation of Cysteine Residues in Long-Lasting Inhibitory Effect of Nitric Oxide on Arterial Tone
Mol. Pharmacol., May 1, 2003; 63(5): 1148 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. F. Benjamim, J. S. Silva, Z. B. Fortes, M. A. Oliveira, S. H. Ferreira, and F. Q. Cunha
Inhibition of Leukocyte Rolling by Nitric Oxide during Sepsis Leads to Reduced Migration of Active Microbicidal Neutrophils
Infect. Immun., July 1, 2002; 70(7): 3602 - 3610.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. E. Da Silva-Santos, M. C. Santos-Silva, F. d. Q. Cunha, and J. Assreuy
The Role of ATP-Sensitive Potassium Channels in Neutrophil Migration and Plasma Exudation
J. Pharmacol. Exp. Ther., March 1, 2002; 300(3): 946 - 951.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. N. Muscara, W. McKnight, F. Lovren, C. R. Triggle, G. Cirino, and J. L. Wallace
Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney, one-clip rats
Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H528 - H535.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1999 by the American Society for Pharmacology and Experimental Therapeutics.