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Vol. 290, Issue 1, 319-324, July 1999
Environmental Health and Occupational Medicine Center, Department
of Pharmacology, Toxicology and Therapeutics, University of Kansas
Medical Center, Kansas City, Kansas
The ontogenic and hormonal regulation of a sulfotransferase,
SULT1B1, was examined. Hepatic RNA was isolated from rats of various
ages from 1 to 90 days. The mRNA for SULT1B1 is low for both sexes
until a dramatic increase (~6-fold) occurs between 15 and 30 days of
age in male rats. SULT1B1 expression then decreases to half of the
maximal level by 90 days of age. The increase in SULT1B1 mRNA in female
rats is less dramatic and occurs between 30 and 45 days of age. SULT1B1
mRNA expression plateaus from 45 to 90 days in female rats. Expression
of SULT1B1 mRNA is comparable in adult male and female rats. RNA was
isolated from hypophysectomized (HX) animals and HX animals treated
with growth hormone [by either male (injection) or female (infusion)
pattern], estradiol, progesterone, or testosterone. HX and HX plus
growth hormone, or HX plus steroid replacement, did not alter SULT1B1
mRNA expression. Pituitary-intact rats were treated with steroidal
compounds dexamethasone (DEX) and pregnenolone-16
-carbonitrile
(PCN). Both DEX and PCN increased expression of SULT1B1 mRNA in male
rats (4- and 3-fold, respectively). However, in female rats, only PCN
induced SULT1B1 mRNA (2-fold), whereas DEX did not induce SULT1B1 in
female rats. Analysis of SULT1B1 protein expression indicated that only
when SULT1B1 mRNA was markedly increased, that is in DEX-treated male
rats, was SULT1B1 protein increased. Thus, although adult male and
female rats have similar SULT1B1 mRNA expressions, the patterns develop ontogenically differently. SULT1B1 is not regulated by pituitary hormones and DEX induces SULT1B1 protein in male rats.
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