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Journal of Pharmacology And Experimental Therapeutics, Vol. 29, Issue 1, 53-67, 1926
Copyright © 1926 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGY OF DENERVATED MAMMALIAN MUSCLE PART I. THE NATURE OF THE SUBSTANCES PRODUCING CONTRACTURE

H. H. DALE 1 and H. S. GASSER 1

1 From the National Institute for Medical Research, Hampstead, London

The sensitiveness of denervated mammalian muscle to acetylcholine and other quaternary bases is associated with that type of action which these substances share with nicotine, and has apparently no relation to their parasympathetic effects. The tension which such substances evoke is not much inferior to the maximum tension which any kind of stimulus can produce in the denervated muscle.






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Copyright © 1926 by the American Society for Pharmacology and Experimental Therapeutics.