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Journal of Pharmacology And Experimental Therapeutics, Vol. 29, Issue 1, 521-532, 1926
Copyright © 1926 by American Society for Pharmacology and Experimental Therapeutics

STUDIES UPON THE COMBINING POWER OF PROTEINS WITH ROSE BENGAL

SANFORD M. ROSENTHAL 1

1 From the Department of Pharmacology, McGill University

A procedure is described which will detect the presence of proteins in extremely high dilutions.

This method is based upon the adsorption of rose bengal. It has been employed as a means of studying quantitatively the relative adsorptive power of different proteins. Characteristic variations with the different proteins occurred in response to heating the solutions of protein and dye.

From the results obtained with gelatin evidence is brought out that molecular aggregation takes place in very dilute aqueous solutions, and that this aggregation increases rapidly in concentrations greater than 0.001 per cent.

Experiments were performed which indicate that the combination of colloids with rose bengal is not a simple chemical union.






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Copyright © 1926 by the American Society for Pharmacology and Experimental Therapeutics.