JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 29, Issue 1, 449-460, 1926
Copyright © 1926 by American Society for Pharmacology and Experimental Therapeutics

VARIATIONS IN BLOOD PRESSURE INDUCED BY REPEATED INJECTIONS OF EXTRACTS OF THE POSTERIOR LOBE OF THE PITUITARY GLAND

E. M. K. GEILING 1 and DAVID CAMPBELL 1

1 From the Department of Pharmacology, Johns Hopkins University

The fall in blood pressure obtained with subsequent injections of depressor-free pituitary extracts given at short intervals and in doses considerably larger than the initial injection is an intrinsic property of the post pituitary hormone, and is probably due to the marked alteration in the cardio-vascular apparatus resulting from the first dose. This "inversion effect" is accordingly not due to the presence of depressor bodies, as is maintained by Hogben and Schlapp.






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Copyright © 1926 by the American Society for Pharmacology and Experimental Therapeutics.