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Vol. 289, Issue 2, 682-687, May 1999
Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland
In vitro electrophysiological techniques were used to examine the
effect of bradykinin on guinea pig trachea and bronchus afferent nerve
endings arising from the nodose or jugular ganglia. The data reveal
that bradykinin activates nerve terminals of jugular C and A
fibers.
Although the fibers were too few in number to study rigorously,
bradykinin also stimulated nodose C fibers innervating the trachea and
bronchus. In contrast, A fibers arising from the nodose ganglion
were unresponsive to bradykinin challenge. The responses in both
jugular C and A fiber types were blocked by a selective bradykinin
B2 receptor antagonist and were not dependent on the
efferent release of sensory neuropeptides. These data indicate that the
sensitivity of guinea pig airway afferent fibers to bradykinin is
dependent more on the ganglionic origin of the cell body than on the
conduction velocity of its axon.
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