JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bosch-Marcé, M.
Right arrow Articles by Rodés, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bosch-Marcé, M.
Right arrow Articles by Rodés, J.

Vol. 289, Issue 1, 194-201, April 1999

Comparison of Two Aquaretic Drugs (Niravoline and OPC-31260) in Cirrhotic Rats with Ascites and Water Retention1

Marta Bosch-Marcé, Jorge-Luis Poo, Wladimiro Jiménez, Nuria Bordas, Alberto Leivas, Manuel Morales-Ruiz, Rosa Maria Muñoz, Manuel Pérez, Vicente Arroyo, Francisca Rivera and Juan Rodés

Hormonal Laboratory (M.B.-M., W.J., N.B., A.L., M.M.-R., R.M.M., M.P., F.R.) and Liver Unit (J.-L.P., V.A., J.R.), Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic Universitari, University of Barcelona, Barcelona, Spain

kappa -Opioid receptor agonists (niravoline) or nonpeptide antidiuretic hormone (ADH) V2 receptor antagonists (OPC-31260) possess aquaretic activity in cirrhosis; however, there is no information concerning the effects induced by the chronic administration of these drugs under this condition. To compare the renal and hormonal effects induced by the long-term oral administration of niravoline, OPC-31260, or vehicle, urine volume, urinary osmolality, sodium excretion, and urinary excretion of aldosterone (ALD) and ADH were measured in basal conditions and for 10 days after the daily oral administration of niravoline, OPC-31260, or vehicle to cirrhotic rats with ascites and water retention. Creatinine clearance, serum osmolality, ADH mRNA expression, and systemic hemodynamics were also measured at the end of the study. Niravoline increased water excretion, peripheral resistance, serum osmolality, and sodium excretion and reduced creatinine clearance, ALD and ADH excretion, and mRNA expression of ADH. OPC-31260 also increased water metabolism and sodium excretion and reduced urinary ALD, although the aquaretic effect was only evident during the first 2 days, and no effects on serum osmolality, renal filtration, and systemic hemodynamics were observed. Therefore, both agents have aquaretic efficacy, but the beneficial therapeutic effects of the long-term oral administration of niravoline are more consistent than those of OPC-31260 in cirrhotic rats with ascites and water retention.

0022-3565/99/2891-0194$03.00/0
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copyright © 1999 by The American Society for Pharmacology and Experimental Therapeutics


This article has been cited by other articles:


Home page
 Lab AnimHome page
S J Henare, D J Mellor, R G Lentle, and P J Moughan
An appraisal of the strengths and weaknesses of newborn and juvenile rat models for researching gastrointestinal development
Lab Anim, July 1, 2008; 42(3): 231 - 245.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. A. Schafer
Abnormal regulation of ENaC: syndromes of salt retention and salt wasting by the collecting duct
Am J Physiol Renal Physiol, August 1, 2002; 283(2): F221 - F235.
[Abstract] [Full Text] [PDF]

Home page
 JRSMHome page
R. W Schrier, M. A Cadnapaphornchai, and M. Ohara
Water retention and aquaporins in heart failure, liver disease and pregnancy
J R Soc Med, January 6, 2001; 94(6): 265 - 269.
[Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
W. Jiménez, C. S.-L. Gal, J. Ros, C. Cano, P. Cejudo, M. Morales-Ruiz, V. Arroyo, M. Pascal, F. Rivera, J.-P. Maffrand, et al.
Long-Term Aquaretic Efficacy of a Selective Nonpeptide V2-Vasopressin Receptor Antagonist, SR121463, in Cirrhotic Rats
J. Pharmacol. Exp. Ther., October 1, 2000; 295(1): 83 - 90.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1999 by the American Society for Pharmacology and Experimental Therapeutics.