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Vol. 287, Issue 3, 1015-1019, December 1998

Magnesium-Dependent Inhibition of N-Methyl-D-Aspartate Receptor-Mediated Synaptic Transmission by Ethanol1

Jeffrey L. Calton, Wilkie A. Wilson and Scott D. Moore

Divisions of Psychiatry (S.D.M.) and Neurology Research (W.A.W.), Durham VA Medical Center, and Departments of Psychiatry (J.L.C., S.D.M.) and Pharmacology (W.A.W.), Duke University Medical Center, Durham, North Carolina

Previous studies have indicated that ethanol (EtOH) has a relatively specific effect on excitatory synaptic transmission by inhibiting function of the N-methyl-D-aspartate receptor. We have found that EtOH potently inhibits N-methyl-D-aspartate-mediated synaptic currents in the basolateral amygdala, a brain region associated with actions of anxiolytic agents such as EtOH. This inhibitory effect of EtOH requires the presence of magnesium (Mg++). The dependence of the effect of EtOH on the presence of Mg++ suggests a possible molecular site of the action of EtOH in the vicinity of Mg++ binding sites on the N-methyl-D-aspartate receptor-channel complex. Because EtOH consumption may result in reductions in free brain Mg++, this dynamic interaction between EtOH and Mg++ may have important implications for understanding the behavioral effects of EtOH.

0022-3565/98/2873-1015$03.00/0
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copyright © 1998 by The American Society for Pharmacology and Experimental Therapeutics


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Copyright © 1998 by the American Society for Pharmacology and Experimental Therapeutics.