JPET Assistant Professor of Medicine (Clinician-Educator)

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Giovannini, M. G.
Right arrow Articles by Blandina, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Giovannini, M. G.
Right arrow Articles by Blandina, P.

Vol. 285, Issue 3, 1219-1225, June 1998

Serotonergic Modulation of Acetylcholine Release from Cortex of Freely Moving Rats1

Maria Grazia Giovannini, Ilaria Ceccarelli, Beatrice Molinari, Marco Cecchi, Joseph Goldfarb and Patrizio Blandina

Dipartimento di Farmacologia Preclinica e Clinica (M.G.G., I.C., B.M., M.C., P.B.), Universitá di Firenze, 50134 Firenze, Italy and Department of Pharmacology, Mount Sinai School of Medicine CUNY (J.G), New York, New York

The modulation of acetylcholine (ACh) release by 5-HT3 receptor activation was studied using in vivo microdialysis. Spontaneous and K+-stimulated ACh release were measured in frontoparietal cortex and hippocampus of freely moving rats. Two consecutive exposures to high K+ produced ACh release of similar magnitude. In the cortex, serotonin (5-HT) failed to alter spontaneous ACh release, but caused a concentration-dependent decrease of K+-evoked ACh release. Phenylbiguanide (PBG) and m-chlorophenylbiguanide, two selective 5-HT3 agonists, mimicked the 5-HT responses, but 8-hydroxy-2-(di-n-propylamino)tetralin, a selective 5-HT1A agonist, was without effect. However, PBG failed to modify K+-evoked ACh release from the hippocampus. Systemic and local administration of a highly selective 5-HT3 antagonist, tropisetron ((3-alpha -tropanyl)1H-indole-carboxylic acid ester) blocked the effect of both 5-HT and PBG. The inhibition of ACh release by PBG was sensitive to tetrodotoxin. These observations provide direct evidence that, in rat cortex, 5-HT modulates in-vivo release of ACh through activation of 5-HT3 receptors.

0022-3565/98/2853-1219$03.00/0
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copyright © 1998 by The American Society for Pharmacology and Experimental Therapeutics


This article has been cited by other articles:


Home page
 Pharmacol. Rev.Home page
K. B. Fink and M. Gothert
5-HT Receptor Regulation of Neurotransmitter Release
Pharmacol. Rev., December 1, 2007; 59(4): 360 - 417.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. Ji and N. Suga
Serotonergic Modulation of Plasticity of the Auditory Cortex Elicited by Fear Conditioning
J. Neurosci., May 2, 2007; 27(18): 4910 - 4918.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. J. Millan, A. Gobert, S. Roux, R. Porsolt, A. Meneses, M. Carli, B. Di Cara, R. Jaffard, J.-M. Rivet, P. Lestage, et al.
The Serotonin1A Receptor Partial Agonist S15535 [4-(Benzodioxan-5-yl)1-(indan-2-yl)piperazine] Enhances Cholinergic Transmission and Cognitive Function in Rodents: A Combined Neurochemical and Behavioral Analysis
J. Pharmacol. Exp. Ther., October 1, 2004; 311(1): 190 - 203.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
J. Melke, L. Westberg, S. Nilsson, M. Landen, H. Soderstrom, F. Baghaei, R. Rosmond, G. Holm, P. Bjorntorp, L.-G. Nilsson, et al.
A Polymorphism in the Serotonin Receptor 3A (HTR3A) Gene and Its Association With Harm Avoidance in Women
Arch Gen Psychiatry, October 1, 2003; 60(10): 1017 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
A. V. Harrell and A. M. Allan
Improvements in Hippocampal-Dependent Learning and Decremental Attention in 5-HT3 Receptor Overexpressing Mice
Learn. Mem., September 1, 2003; 10(5): 410 - 419.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1998 by the American Society for Pharmacology and Experimental Therapeutics.