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Vol. 285, Issue 3, 1031-1038, June 1998
Departments of
Anesthesiology (T.L.Y.) and
Pharmacology (D.M.D.,
T.L.Y.), University of California, San Diego, California
Intrathecal administration of nonsteroidal anti-inflammatory drugs in
the rat blocks the thermal hyperalgesia induced by tissue injury, which
suggests a role for spinal cyclooxygenase (COX) products in this
facilitated state. Two isozymes of the COX enzyme have been reported,
COX-1 and COX-2, but the agents thus far examined are not isozyme
selective. We examined the effects of intrathecally (i.t.) or
systemically (i.p.) administered S(+)-ibuprofen (a
nonselective COX inhibitor) or
1-[(4-methysulfonyl)phenyl]-3-tri-fluoromethyl-5-(4-fluorophenyl) pyrazole (SC58125; a COX-2 selective inhibitor) on carrageenan-induced thermal hyperalgesia (reduced hindpaw-withdrawal latency). The following observations were made: 1) Thermal hyperalgesia otherwise observed during the first 170 min was blocked in a dose-dependent manner by S(+)-ibuprofen or SC58125 administered i.t. or
i.p. before carrageenan treatment. 2) Intraperitoneal, but not i.t., administration of either inhibitor after the establishment of hyperalgesia (170 min after carrageenan injection) reversed thermal hyperalgesia in a dose-dependent manner. Thus, the initial component of
thermal hyperalgesia after tissue injury was blocked by systemic or
spinal administration of both COX inhibitors, whereas established hyperalgesia was reversed only by systemic inhibitors. This study demonstrates that at least spinal COX-2, if not both COX-1 and COX-2,
are necessary for the initiation of thermal hyperalgesia, whereas
nonspinal sources of prostanoids (synthesized by COX-2 and perhaps also
COX-1) are important for the maintenance of thermal hyperalgesia
associated with tissue injury and inflammation.
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