![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 285, Issue 2, 908-914, May 1998
Department of Psychology (M.Z.),
University of Wisconsin-Madison,
and Department of Psychiatry (A.E.K.), University of Wisconsin-Madison
Medical School, Madison, Wisconsin; and
Neuropsychiatry Research
Institute (B.A.G.), Fargo, North Dakota
The present study was designed to further investigate the nature of
feeding induced by opioid stimulation of the nucleus accumbens through
an examination of the effects of intra-accumbens (ACB) opioids on
macronutrient selection. In 3-hr tests of free-feeding (satiated) rats,
intra-ACB administration of the mu receptor agonist D-Ala2,N,Me-Phe4,Gly-ol5-enkephalin
(DAMGO; 0, 0.025, 0.25 and 2.5 µg bilaterally) markedly enhanced the
intake of fat or carbohydrate when the diets were presented
individually (although the effect on fat intake was much greater in
magnitude). Intra-ACB injections of DAMGO, however, produced potent
preferential stimulatory effects on fat ingestion with no effect on
carbohydrate ingestion when both fat and carbohydrate diets were
present simultaneously. Moreover, this selective stimulation of fat
intake was independent of base-line diet preference and could be
blocked by systemic injection of naltrexone (5 mg/kg). We also examined
the effect of 24-hr food deprivation on the pattern of macronutrient
intake in rats with access to both carbohydrate and fat. In contrast to
the DAMGO-induced selective enhancement of fat intake, food deprivation
significantly increased the intake of both diets to the same extent;
however, in this case, only the stimulated fat intake was blocked by
systemic naltrexone. Intra-ACB administration of DAMGO in hungry rats
produced an effect similar to that observed in free-feeding rats;
preference was strongly shifted to fat intake. Similarly, the opioid
antagonist naltrexone (20 µg) infused directly into ACB
preferentially decreased fat intake in hungry rats. These findings
suggest that endogenous opioids within the ventral striatum may
participate in the mechanisms governing preferences for highly
palatable foods, especially those rich in fat.
This article has been cited by other articles:
|
|
 |
|
  G.-Q. Chang, V. Gaysinskaya, O. Karatayev, and S. F. Leibowitz Maternal High-Fat Diet and Fetal Programming: Increased Proliferation of Hypothalamic Peptide-Producing Neurons That Increase Risk for Overeating and Obesity J. Neurosci., November 12, 2008; 28(46): 12107 - 12119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Sahr, D. K. Sindelar, J. T. Alexander-Chacko, B. J. Eastwood, C. H. Mitch, and M. A. Statnick Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582 Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R463 - R471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. E. Ghitza, S. G. Nair, S. A. Golden, S. M. Gray, J. L. Uejima, J. M. Bossert, and Y. Shaham Peptide YY3-36 Decreases Reinstatement of High-Fat Food Seeking during Dieting in a Rat Relapse Model J. Neurosci., October 24, 2007; 27(43): 11522 - 11532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zheng, L. M. Patterson, and H.-R. Berthoud Orexin Signaling in the Ventral Tegmental Area Is Required for High-Fat Appetite Induced by Opioid Stimulation of the Nucleus Accumbens J. Neurosci., October 10, 2007; 27(41): 11075 - 11082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Naleid, M. K. Grace, M. Chimukangara, C. J. Billington, and A. S. Levine Paraventricular opioids alter intake of high-fat but not high-sucrose diet depending on diet preference in a binge model of feeding Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R99 - R105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fichna, A. Janecka, J. Costentin, and J.-C. Do Rego The Endomorphin System and Its Evolving Neurophysiological Role Pharmacol. Rev., March 1, 2007; 59(1): 88 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Smith and K. C. Berridge Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum J. Neurosci., February 14, 2007; 27(7): 1594 - 1605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-Q. Chang, O. Karatayev, R. Ahsan, V. Gaysinskaya, Z. Marwil, and S. F. Leibowitz Dietary fat stimulates endogenous enkephalin and dynorphin in the paraventricular nucleus: role of circulating triglycerides Am J Physiol Endocrinol Metab, February 1, 2007; 292(2): E561 - E570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Will, W. M. Vanderheyden, and A. E. Kelley Striatal opioid peptide gene expression differentially tracks short-term satiety but does not vary with negative energy balance in a manner opposite to hypothalamic NPY Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R217 - R226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. S. Densmore, N. M. Morton, J. J. Mullins, and J. R. Seckl 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Induction in the Arcuate Nucleus by High-Fat Feeding: A Novel Constraint to Hyperphagia? Endocrinology, September 1, 2006; 147(9): 4486 - 4495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. S. Hnasko, F. A. Perez, A. D. Scouras, E. A. Stoll, S. D. Gale, S. Luquet, P. E. M. Phillips, E. J. Kremer, and R. D. Palmiter Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia PNAS, June 6, 2006; 103(23): 8858 - 8863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. la Fleur, H. Houshyar, M. Roy, and M. F. Dallman Choice of Lard, But Not Total Lard Calories, Damps Adrenocorticotropin Responses to Restraint Endocrinology, May 1, 2005; 146(5): 2193 - 2199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-Q. Chang, O. Karatayev, Z. Davydova, and S. F. Leibowitz Circulating Triglycerides Impact on Orexigenic Peptides and Neuronal Activity in Hypothalamus Endocrinology, August 1, 2004; 145(8): 3904 - 3912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Will, E. B. Franzblau, and A. E. Kelley Nucleus Accumbens {micro}-Opioids Regulate Intake of a High-Fat Diet via Activation of a Distributed Brain Network J. Neurosci., April 1, 2003; 23(7): 2882 - 2888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Brugman, D. J. Clegg, S. C. Woods, and R. J. Seeley Combined Blockade of Both {micro}- and {kappa}-Opioid Receptors Prevents the Acute Orexigenic Action of Agouti-Related Protein Endocrinology, November 1, 2002; 143(11): 4265 - 4270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Clegg, E. L. Air, S. C. Woods, and R. J. Seeley Eating Elicited by Orexin-A, But Not Melanin-Concentrating Hormone, Is Opioid Mediated Endocrinology, August 1, 2002; 143(8): 2995 - 3000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Glass, C. J. Billington, and A. S. Levine Naltrexone administered to central nucleus of amygdala or PVN: neural dissociation of diet and energy Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R86 - R92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Glass, C. J. Billington, and A. S. Levine Role of lipid type on morphine-stimulated diet selection in rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1999; 277(5): R1345 - R1350. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
