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Vol. 285, Issue 2, 805-812, May 1998
Department of Psychiatry and Behavioral Neurosciences and Cellular
and Clinical Neurobiology Training Program, Wayne State University
School of Medicine, Detroit, Michigan
5-Hydroxytryptamine (5-HT; serotonin) administration enhances GABAergic
synaptic activity recorded in pyramidal neurons of the CA1 region of
hippocampus. Previous studies have attributed this effect to the
activation of HT-53 receptors located on GABAergic interneurons. During unrelated experiments, we noticed that under our
recording conditions, 5-HT can still increase GABAergic synaptic activity after the complete blockade of 5-HT3 receptors.
This indicated the involvement of an additional 5-HT receptor subtype. Therefore, we reinvestigated the effects of 5-HT on GABAergic synaptic
activity recorded in pyramidal cells of the CA1 region. The ability of
5-HT to increase GABAergic synaptic activity in the presence of
5-HT3 receptor blockade was mimicked by the selective 5-HT2 agonist
(±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and blocked by the
selective 5-HT2 antagonist ketanserin. This indicated that
the additional 5-HT receptor belongs to 5-HT2 receptor family. 5-HT2 receptor activation resulted in an increase
in the frequency of spontaneous inhibitory postsynaptic currents as
well as a shift in their amplitude distribution toward larger sizes. These effects were absent in the presence of tetrodotoxin. We interpret
these results to indicate that 5-HT2 receptors activate GABAergic interneurons in the slice, leading to an increase in GABAergic synaptic activity onto pyramidal cells of the CA1 region.
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