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Vol. 285, Issue 1, 335-341, April 1998
Department of Public Health, School of Pharmaceutical Sciences,
Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108, Japan
(T.T.-K., M.S., N.I.),
Department of Molecular and Biochemical
Toxicology, Faculty of Pharmaceutical Sciences, Tohoku University,
Aoba-ku, Sendai 980-77, Japan (A.N.) and
Department of Pathology (I),
Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113, Japan
(N.Y.)
Inorganic mercury has a high affinity for the kidneys and causes acute
renal failure. The present investigation was designed to determine the
cause of the strain difference in sensitivity of mice to the renal
toxicity of inorganic mercury. Renal damage caused by HgCl2
was estimated by histopathological and biochemical assessment, such as
increase in blood urea nitrogen and plasma creatinine levels, and was
found to be more remarkable in C3H/He than in C57BL/6 mice. Increase in
renal lipid peroxidation in C3H/He was greater than that in C57BL/6
mice. However, no strain difference was observed in renal activities of
glutathione (GSH) peroxidase, superoxide dismutase and GSH
S-transferase in HgCl2-untreated mice. The
GSH content and activities of catalase and GSSG reductase in kidney of
HgCl2-untreated mice were higher in C3H/He than in C57BL/6.
Background level of renal metallothionein content and the extent of
metallothionein induction by HgCl2 showed no strain difference. On the other hand, renal mercury accumulation was higher
and urinary mercury excretion was lower in C3H/He than in C57BL/6. The
activity of renal 
-glutamyltranspeptidase (-GTP), which plays a
key role in renal mercury accumulation, was higher in C3H/He than in
C57BL/6. Furthermore, the increase in blood urea nitrogen by
HgCl2, renal mercury accumulation and renal -GTP activity in B6C3F1 mice were intermediate between those of the parent
strains. These results suggest that the strain difference in renal
toxicity of inorganic mercury seems to be caused by the discrepancy in
renal mercury accumulation, and therefore, renal -GTP may be an
important factor determining the susceptibility of mice to the toxic
action of inorganic mercury.
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