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Vol. 284, Issue 3, 1104-1111, March 1998
5 and 7 Nicotinic
Receptor Subunit Genes1
Institute for Behavioral Genetics, University of Colorado, Boulder,
Colorado
Restriction fragment length polymorphisms (rflps) have been identified
for the nicotinic ACh receptor subunit genes 
5 and 7 between two
mouse strains (C3H/2ibg and DBA/2ibg) that differ in sensitivity to the
convulsant effects of nicotine. In the study reported here, F2 animals
derived from these two parental stains were tested for their
sensitivity to the convulsant effects of nicotine as measured by
seizure frequency and overall sensitivity score. Subsequently, the
animals were genotyped for the 5 and 7 rflps. In addition, levels
of -bungarotoxin (-BTX) binding were measured in four brain
regions (colliculi, hippocampus, hypothalamus and striatum) to
determine whether there is a correlation among -BTX binding levels,
sensitivity to nicotine and nicotinic ACh receptor subunit genotype. A
significant relationship was observed between 5 and 7 genotype
and sensitivity to nicotine. In addition, the 7 rflp significantly
correlated with levels of -BTX binding in hippocampus, colliculi and
striatum. The 5 rflp did not correlate with -BTX binding levels
in any brain region. Levels of -BTX binding did not correlate with
nicotine-induced seizure sensitivity or overall nicotine sensitivity
score in any of the four brain regions examined.
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