![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 284, Issue 2, 678-686, February 1998
Anesthesiology Research Laboratory, Department of Anesthesiology,
Tufts University School of Medicine, Baystate Medical Center,
Springfield, Massachusetts
The opioid abstinence syndrome is associated with spinal excitatory
amino acid (EAA) release, hyperalgesia and long-term changes in dorsal
horn cellular excitability. N-Methyl-D-aspartate (NMDA) receptor antagonism attenuates opioid tolerance but also blocks EAA
release during abstinence. This study examines the effect of repetitive
abstinence, and NMDA receptor antagonism during abstinence, on thermal
nociceptive thresholds and spinal tolerance. An intrathecal catheter
system driven by a miniosmotic pump (Alzet 2002 0.5 µl/h) was
implanted in rats (n = 4-8/group) and delivered alternating daily infusions of morphine (40 nmol/h), saline or MK801
(MK) (10 nmol/h). Abstinence was induced by infusion of saline or MK.
Groups were: saline, 7 days; morphine, 7 days; abstinence (saline), day
6; abstinence (saline), days 4 and 6; abstinence (saline), days 2, 4 and 6; morphine, except on days 2, 4 and 6 when morphine (8 nmol/h) was
infused; abstinence (MK), day 6; abstinence (MK), days 2, 4 and 6; and
saline with MK, days 2, 4 and 6. Analgesia was measured daily (hot
plate). Sixteen hours after termination of the infusion period (day 8)
groups received intrathecal morphine (100 nmol) to assess tolerance.
Hyperalgesia was most pronounced in groups subjected to repetitive
abstinence, and least evident in groups in which continuous infusion
was maintained or in which MK was administered during abstinence. MK
administered during abstinence did not prevent tolerance. These results
show that repetitive opioid abstinence is associated with progressive hyperalgesia mediated via NMDA receptor activation, but
that NMDA receptor antagonism during such periods of abstinence does
not prevent progressive opioid tolerance.
This article has been cited by other articles:
|
|
 |
|
  D. P. Alford, P. Compton, and J. H. Samet Acute Pain Management for Patients Receiving Maintenance Methadone or Buprenorphine Therapy Ann Intern Med, January 17, 2006; 144(2): 127 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. L. Tawfik, M. L. LaCroix-Fralish, N. Nutile-McMenemy, and J. A. DeLeo Transcriptional and Translational Regulation of Glial Activation by Morphine in a Rodent Model of Neuropathic Pain J. Pharmacol. Exp. Ther., June 1, 2005; 313(3): 1239 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. W. H. Peng, P. S. Tumber, and D. Gourlay Review article: Perioperative pain management of patients on methadone therapy: [Expose de synthese : Traitement de la douleur perioperatoire chez les patients sous therapie a la methadone] Can J Anesth, May 1, 2005; 52(5): 513 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-P. Yang, C.-C. Yeh, C.-S. Wong, C.-T. Wu, S. Mercadante, P. Villari, P. Ferrera, and E. Arcuri Local Anesthetic Switching for Intrathecal Tachyphylaxis in Cancer Patients with Pain * Response Anesth. Analg., February 1, 2004; 98(2): 557 - 558. [Full Text] [PDF]
|
|
|
|
|
|
X. Li and J. D. Clark Hyperalgesia During Opioid Abstinence: Mediation by Glutamate and Substance P Anesth. Analg., October 1, 2002; 95(4): 979 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mao, B. Sung, R.-R. Ji, and G. Lim Chronic Morphine Induces Downregulation of Spinal Glutamate Transporters: Implications in Morphine Tolerance and Abnormal Pain Sensitivity J. Neurosci., September 15, 2002; 22(18): 8312 - 8323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mao, B. Sung, R.-R. Ji, and G. Lim Neuronal Apoptosis Associated with Morphine Tolerance: Evidence for an Opioid-Induced Neurotoxic Mechanism J. Neurosci., September 1, 2002; 22(17): 7650 - 7661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, M. S. Angst, and J. D. Clark Opioid-Induced Hyperalgesia and Incisional Pain Anesth. Analg., July 1, 2001; 93(1): 204 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Park, C. Y. Chiang, J. W. Hu, and B. J. Sessle Neuroplasticity Induced by Tooth Pulp Stimulation in Trigeminal Subnucleus Oralis Involves NMDA Receptor Mechanisms J Neurophysiol, May 1, 2001; 85(5): 1836 - 1846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Dunbar, I. G. Karamov, and H. Buerkle The Effect of Spinal Ibuprofen on Opioid Withdrawal in the Rat Anesth. Analg., August 1, 2000; 91(2): 417 - 422. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
