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Vol. 284, Issue 2, 549-552, February 1998

Leukotriene D4 Contractions in Human Airways are Blocked by SK&F 96365, an Inhibitor of Receptor-Mediated Calcium Entry

Isabelle Gorenne, Carlos Labat, Jean-Pierre Gascard, Xavier Norel, Nabila Nashashibi and Charles Brink

Laboratoire d'Anatomopathologie (N.N.) and CNRS ERS 566 (I.G., C.L., J.P.G., X.N., C.B.) Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France

In human bronchial muscle preparations, nifedipine (3 µM) significantly inhibited the histamine, ACh and KCl contractions. However, the dihydropyridine did not modify the contractile responses induced by either leukotriene D4 (LTD4) or anti-human IgE (a-IgE). In human airways, SK&F 96365 (30 µM and 100 µM) markedly reduced the KCl and, at the higher concentration, LTD4 maximal contractions. In addition, when preparations were treated with nifedipine (3 µM), SK&F 96365 (100 µM) significantly blocked responses to both LTD4 and a-IgE. The calcium chelating agent ethylene glycol-bis (beta -amino-ethyl ether) N,N,N',N'-tetraacetic acid (4 mM) also inhibited the a-IgE-induced contractions. These data demonstrate that the nifedipine-resistant component of the LTD4 and a-IgE contractions was inhibited by SK&F 96365 and suggest that the cysteinyl-leukotriene receptor in human airways may be intimately linked with a receptor-operated calcium-entry mechanism.

0022-3565/98/2842-0549$03.00/0
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copyright © 1998 by The American Society for Pharmacology and Experimental Therapeutics


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