![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 284, Issue 1, 388-398, 1998
Department of Pharmacology, College of Medicine, The University of
Tennessee Center for Health Sciences, Memphis, Tennessee 38163 (M.M.M.,
J.L.H., K.U.M.),
Southern College of Optometry Memphis, Tennessee
(I.F.B.), and
LeMoyne Owen College, Memphis, Tennessee (M.R.U.)
This study investigated the signal transduction mechanisms of
angiotensin-(1-7) [Ang-(1-7)]- and Ang II-stimulated arachidonic acid (AA) release for prostaglandin (PG) production in rabbit aortic
vascular smooth muscle cells. Ang II and Ang-(1-7) enhanced AA release
in cells prelabeled with [3H]AA. However,
6-keto-PGF1
synthesis produced by Ang II was much less
than that caused by Ang-(1-7). In the presence of the lipoxygenase
inhibitor baicalein, Ang II enhanced production of 6-keto-PGF1 to a greater degree than Ang-(1-7).
Angiotensin type (AT)1 receptor antagonist DUP-753
inhibited only Ang II-induced [3H]AA release, whereas the
AT2 receptor antagonist PD-123319 inhibited both Ang II-
and Ang-(1-7)-induced [3H]AA release. Ang-(1-7)
receptor antagonist D-Ala7-Ang-(1-7) inhibited
the effect of Ang-(1-7), but not of Ang II. In cells transiently
transfected with cytosolic phospholipase A2
(cPLA2), mitogen-activated protein (MAP) kinase or
Ca++-/calmodulin-dependent protein (CAM) kinase II
antisense oligonucleotides, Ang-(1-7)- and Ang II-induced
[3H]AA release was attenuated. The CaM kinase II
inhibitor KN-93 and the MAP kinase kinase inhibitor PD-98059 attenuated
both Ang-(1-7)- and Ang II-induced cPLA2 activity and
[3H]AA release. Ang-(1-7) and Ang II also increased CaM
kinase II and MAP kinase activities. Although KN-93 attenuated MAP
kinase activity, PD-98059 did not affect CaM kinase II activity. Both Ang II and Ang-(1-7) caused translocation of cytosolic
PLA2 to the nuclear envelope. These data show that
Ang-(1-7) and Ang II stimulate AA release and prostacyclin synthesis
via activation of distinct types of AT receptors. Both
peptides appear to stimulate CaM kinase II, which in turn,
via MAP kinase activation, enhances cPLA2
activity and release of AA for PG synthesis.
This article has been cited by other articles:
|
|
 |
|
  B. Rentzsch, M. Todiras, R. Iliescu, E. Popova, L. A. Campos, M. L. Oliveira, O. C. Baltatu, R. A. Santos, and M. Bader Transgenic Angiotensin-Converting Enzyme 2 Overexpression in Vessels of SHRSP Rats Reduces Blood Pressure and Improves Endothelial Function Hypertension, November 1, 2008; 52(5): 967 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Vaajanen, H. Vapaatalo, H. Kautiainen, and O. Oksala Angiotensin (1-7) Reduces Intraocular Pressure in the Normotensive Rabbit Eye Invest. Ophthalmol. Vis. Sci., June 1, 2008; 49(6): 2557 - 2562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Pavicevic, C. C. Leslie, and K. U. Malik cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells J. Lipid Res., April 1, 2008; 49(4): 724 - 737. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pignone, A. D. Rosso, K B. Brosnihan, F. Perfetto, R. Livi, G. Fiori, S. Guiducci, M. Cinelli, V. Rogai, A. Tempestini, et al. Reduced circulating levels of angiotensin-(1 7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control Ann Rheum Dis, October 1, 2007; 66(10): 1305 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. Yaghini, F. Li, and K. U. Malik Expression and Mechanism of Spleen Tyrosine Kinase Activation by Angiotensin II and Its Implication in Protein Synthesis in Rat Vascular Smooth Muscle Cells J. Biol. Chem., June 8, 2007; 282(23): 16878 - 16890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Botelho-Santos, W. O. Sampaio, T. L. Reudelhuber, M. Bader, M. J. Campagnole-Santos, and R. A. Souza dos Santos Expression of an angiotensin-(1-7)-producing fusion protein in rats induced marked changes in regional vascular resistance Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2485 - H2490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Menon, D. R. Soto-Pantoja, M. F. Callahan, J. M. Cline, C. M. Ferrario, E. A. Tallant, and P. E. Gallagher Angiotensin-(1-7) Inhibits Growth of Human Lung Adenocarcinoma Xenografts in Nude Mice through a Reduction in Cyclooxygenase-2 Cancer Res., March 15, 2007; 67(6): 2809 - 2815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Albrecht Angiotensin-(1-7)-induced plasticity changes in the lateral amygdala are mediated by COX-2 and NO Learn. Mem., March 8, 2007; 14(3): 177 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Paizis, C Tikellis, M E Cooper, J M Schembri, R A Lew, A I Smith, T Shaw, F J Warner, A Zuilli, L M Burrell, et al. Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2 Gut, December 1, 2005; 54(12): 1790 - 1796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iwata, R. T. Cowling, D. Gurantz, C. Moore, S. Zhang, J. X.-J. Yuan, and B. H. Greenberg Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2356 - H2363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Gurzu, M. Costuleanu, S. M. Slatineanu, A. Ciobanu, and G. Petrescu Are Multiple Angiotensin Receptor Types Involved in Angiotensin (1-7) Actions on Isolated Rat Portal Vein? Journal of Renin-Angiotensin-Aldosterone System, June 1, 2005; 6(2): 90 - 95. [Abstract] [PDF]
|
|
|
|
|
|
F. A. Yaghini, C. Zhang, J.-H. Parmentier, A. M. Estes, N. Jafari, S. A. Schaefer, and K. U. Malik Contribution of Arachidonic Acid Metabolites Derived Via Cytochrome P4504A to Angiotensin II-Induced Neointimal Growth Hypertension, June 1, 2005; 45(6): 1182 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Walters, T. A. Gaspari, and R. E. Widdop Angiotensin-(1-7) Acts as a Vasodepressor Agent Via Angiotensin II Type 2 Receptors in Conscious Rats Hypertension, May 1, 2005; 45(5): 960 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S Richmond, E A. Tallant, P. E Gallagher, C. M Ferrario, and W. B Strawn Angiotensin II stimulates arachidonic acid release from bone marrow stromal cells Journal of Renin-Angiotensin-Aldosterone System, December 1, 2004; 5(4): 176 - 182. [Abstract] [PDF]
|
|
|
|
 |
|
 H. J. Han, S. H. Park, and Y. J. Lee Signaling cascade of ANG II-induced inhibition of {alpha}-MG uptake in renal proximal tubule cells Am J Physiol Renal Physiol, April 1, 2004; 286(4): F634 - F642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Tallant and M. A. Clark Molecular Mechanisms of Inhibition of Vascular Growth by Angiotensin-(1-7) Hypertension, October 1, 2003; 42(4): 574 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. S. Santos, A. C. S. e Silva, C. Maric, D. M. R. Silva, R. P. Machado, I. de Buhr, S. Heringer-Walther, S. V. B. Pinheiro, M. T. Lopes, M. Bader, et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas PNAS, July 8, 2003; 100(14): 8258 - 8263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. O. Sampaio, A. A. S. Nascimento, and R. A. S. Santos Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems: Systemic and regional hemodynamic effects of angiotensin-(1-7) in rats Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H1985 - H1994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kalyankrishna and K. U. Malik Norepinephrine-Induced Stimulation of p38 Mitogen-Activated Protein Kinase Is Mediated by Arachidonic Acid Metabolites Generated by Activation of Cytosolic Phospholipase A2 in Vascular Smooth Muscle Cells J. Pharmacol. Exp. Ther., February 1, 2003; 304(2): 761 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fatima, F. A. Yaghini, A. Ahmed, Z. Khandekar, and K. U. Malik CaM kinase II{alpha} mediates norepinephrine-induced translocation of cytosolic phospholipase A2 to the nuclear envelope J. Cell Sci., January 15, 2003; 116(2): 353 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-W. Hu, R. Kerb, X.-Y. Shi, T. Wei-Lavery, and B. B. Hoffman Angiotensin II Increases Expression of Cyclooxygenase-2: Implications for the Function of Vascular Smooth Muscle Cells J. Pharmacol. Exp. Ther., November 1, 2002; 303(2): 563 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ren, J. L. Garvin, and O. A. Carretero Vasodilator Action of Angiotensin-(1-7) on Isolated Rabbit Afferent Arterioles Hypertension, March 1, 2002; 39(3): 799 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Muthalif, N. A. Karzoun, I. F. Benter, L. Gaber, F. Ljuca, M. R. Uddin, Z. Khandekar, A. Estes, and K. U. Malik Functional Significance of Activation of Calcium/Calmodulin-Dependent Protein Kinase II in Angiotensin II-Induced Vascular Hyperplasia and Hypertension Hypertension, February 1, 2002; 39(2): 704 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Muthalif, Y. Hefner, S. Canaan, J. Harper, H. Zhou, J.-H. Parmentier, R. Aebersold, M. H. Gelb, and K. U. Malik Functional Interaction of Calcium-/Calmodulin-dependent Protein Kinase II and Cytosolic Phospholipase A2 J. Biol. Chem., October 19, 2001; 276(43): 39653 - 39660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fatima, Z. Khandekar, J.-H. Parmentier, and K. U. Malik Cytosolic Phospholipase A2 Activation by the p38 Kinase Inhibitor SB203580 in Rabbit Aortic Smooth Muscle Cells J. Pharmacol. Exp. Ther., July 1, 2001; 298(1): 331 - 338. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. A. Stockton and B. S. Jacobson Modulation of Cell-Substrate Adhesion by Arachidonic Acid: Lipoxygenase Regulates Cell Spreading and ERK1/2-inducible Cyclooxygenase Regulates Cell Migration in NIH-3T3 Fibroblasts Mol. Biol. Cell, July 1, 2001; 12(7): 1937 - 1956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. P. Machado, R. A. S. Santos, and S. P. Andrade Mechanisms of angiotensin-(1-7)-induced inhibition of angiogenesis Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R994 - R1000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Clark, D. I. Diz, and E. A. Tallant Angiotensin-(1-7) Downregulates the Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells Hypertension, April 1, 2001; 37(4): 1141 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. HANDA Characterization and Signaling of the AT4 Receptor in Human Proximal Tubule Epithelial (HK-2) Cells J. Am. Soc. Nephrol., March 1, 2001; 12(3): 440 - 449. [Abstract] [Full Text]
|
|
|
|
|
|
J.-H. Parmentier, M. M. Muthalif, A. T. Nishimoto, and K. U. Malik 20-Hydroxyeicosatetraenoic Acid Mediates Angiotensin II-Induced Phospholipase D Activation in Vascular Smooth Muscle Cells Hypertension, February 1, 2001; 37(2): 623 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Fernandes, Z. B. Fortes, D. Nigro, R. C. A. Tostes, R. A. S. Santos, and M. H. Catelli de Carvalho Potentiation of Bradykinin by Angiotensin-(1-7) on Arterioles of Spontaneously Hypertensive Rats Studied In Vivo Hypertension, February 1, 2001; 37(2): 703 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Stanke-Labesque, P. Devillier, S. Veitl, F. Caron, J.-L. Cracowski, and G. Bessard Cysteinyl leukotrienes are involved in angiotensin II-induced contraction of aorta from spontaneously hypertensive rats Cardiovasc Res, January 1, 2001; 49(1): 152 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Touyz and E. L. Schiffrin Signal Transduction Mechanisms Mediating the Physiological and Pathophysiological Actions of Angiotensin II in Vascular Smooth Muscle Cells Pharmacol. Rev., December 1, 2000; 52(4): 639 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Muthalif, N. A. Karzoun, L. Gaber, Z. Khandekar, I. F. Benter, A. E. Saeed, J.-H. Parmentier, A. Estes, and K. U. Malik Angiotensin II-Induced Hypertension : Contribution of Ras GTPase/Mitogen-Activated Protein Kinase and Cytochrome P450 Metabolites Hypertension, October 1, 2000; 36(4): 604 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. HANDA Metabolism Alters the Selectivity of Angiotensin-(1-7) Receptor Ligands for Angiotensin Receptors J. Am. Soc. Nephrol., August 1, 2000; 11(8): 1377 - 1386. [Abstract] [Full Text]
|
|
|
|
|
|
F. Stanke-Labesque, P. Devillier, P. Bedouch, J. L. Cracowski, O. Chavanon, and G. Bessard Angiotensin II-induced contractions in human internal mammary artery: effects of cyclooxygenase and lipoxygenase inhibition Cardiovasc Res, August 1, 2000; 47(2): 376 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Gironacci, M. Vatta, M. Rodriguez-Fermepin, B. E. Fernandez, and C. Pena Angiotensin-(1-7) Reduces Norepinephrine Release Through a Nitric Oxide Mechanism in Rat Hypothalamus Hypertension, June 1, 2000; 35(6): 1248 - 1252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Muthalif, I. F. Benter, Z. Khandekar, L. Gaber, A. Estes, S. Malik, J.-H. Parmentier, V. Manne, and K. U. Malik Contribution of Ras GTPase/MAP Kinase and Cytochrome P450 Metabolites to Deoxycorticosterone-Salt-Induced Hypertension Hypertension, January 1, 2000; 35(1): 457 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Tallant, D. I. Diz, and C. M. Ferrario Antiproliferative Actions of Angiotensin-(1-7) in Vascular Smooth Muscle Hypertension, October 1, 1999; 34(4): 950 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zhu, C. H. Gelband, P. Posner, and C. Sumners Angiotensin II Decreases Neuronal Delayed Rectifier Potassium Current: Role of Calcium/Calmodulin-Dependent Protein Kinase II J Neurophysiol, September 1, 1999; 82(3): 1560 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. M. Roks, P. P. van Geel, Y. M. Pinto, H. Buikema, R. H. Henning, D. de Zeeuw, and W. H. van Gilst Angiotensin-(1–7) Is a Modulator of the Human Renin-Angiotensin System Hypertension, August 1, 1999; 34(2): 296 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Strawn, C. M. Ferrario, and E. A. Tallant Angiotensin-(1–7) Reduces Smooth Muscle Growth After Vascular Injury Hypertension, January 1, 1999; 33(1): 207 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Muthalif, I. F. Benter, N. Karzoun, S. Fatima, J. Harper, M. R. Uddin, and K. U. Malik 20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells PNAS, October 13, 1998; 95(21): 12701 - 12706. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
