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Vol. 283, Issue 1, 59-65, 1997
Preclinical Research and Development, Astra Pain Control AB
(T.M.,C-J.D.), Södertälje, Sweden,
Department of Biology,
Yamagata University (T.O.), Yamagata, Japan;
Division of Clinical
Immunology, Karolinska Hospital (E.F.), Stockholm, Sweden;
Pharmacology
1, Astra Draco AB (K.R., E.S.), Lund, Sweden,
Lab. de Pesquisas em
Microcirculacáo (E.S.), Univ. do Estado do Rio de Janeiro, Brazil
Ropivacaine, a new local anesthetic, is currently being investigated
for the treatment of ulcerative colitis, with promising results so far.
The aim of this study was to examine anti-inflammatory properties of
ropivacaine with regard to its effects on vascular permeability and
inflammatory leukocyte behavior in vivo. The effects on
leukocyte rolling, firm adhesion and vascular permeability were
examined in the hamster cheek pouch microvasculature via intravital microscopy, and the effects on leukocyte adhesion molecules were examined in vitro by means of flow cytometry. In large
venules, leukocyte adhesion induced by topical leukotriene
B4 (LTB4) was almost completely inhibited
during the combined application of ropivacaine and LTB4.
The spontaneous rolling leukocyte flux was reduced by 72%, the rolling
leukocyte fraction by 47% and the total leukocyte flux, which reflects
blood flow, by 47%. In postcapillary venules, ropivacaine abolished
rolling and LTB4-induced firm adhesion of leukocytes.
LTB4 challenge also resulted in increased plasma exudation
that was almost completely inhibited by ropivacaine. Moreover,
ropivacaine inhibited the tumor necrosis factor 
-induced up-regulation of CD11b/CD18 and L-selectin shedding by human leukocytes in vitro. Our results suggest that ropivacaine exerts
anti-inflammatory activity, and this appears to be mediated to a
significant extent by inhibition of both leukocyte rolling and
adhesion.
This article has been cited by other articles:
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  S. C. Schafer, D. N. Sehrt, M. Kamler, H. Jakob, and H.-A. Lehr Paradoxical attenuation of leukocyte rolling in response to ischemia- reperfusion and extracorporeal blood circulation in inflamed tissue Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H330 - H335. [Abstract] [Full Text] [PDF]
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 A. Gottschalk, M.-A. Burmeister, P. Radtke, M. Krieg, F. Farokhzad, S. Kreissl, M. Strauss, and T. Standl Continuous Wound Infiltration with Ropivacaine Reduces Pain and Analgesic Requirement After Shoulder Surgery Anesth. Analg., October 1, 2003; 97(4): 1086 - 1091. [Abstract] [Full Text] [PDF]
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K. Hahnenkamp, G. Theilmeier, H. K. Van Aken, and C. W. Hoenemann The Effects of Local Anesthetics on Perioperative Coagulation, Inflammation, and Microcirculation Anesth. Analg., June 1, 2002; 94(6): 1441 - 1447. [Full Text] [PDF]
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 T. Martinsson, T. Ljung, C. Rubio, and P. M. Hellström Beneficial Effects of Ropivacaine in Rat Experimental Colitis J. Pharmacol. Exp. Ther., November 1, 1999; 291(2): 642 - 647. [Abstract] [Full Text]
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T. Martinsson Ropivacaine Inhibits Serum-Induced Proliferation of Colon Adenocarcinoma Cells In Vitro J. Pharmacol. Exp. Ther., February 1, 1999; 288(2): 660 - 664. [Abstract] [Full Text]
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